OBJECTIVE: To determine the association of the metabolic syndrome (MS) with cognitive decline in a Chinese older population. METHODS: In a prospective cohort study of 1,352 community-living Chinese older adults without cognitive impairment (Mini Mental State Examination, MMSE <24) and without cardiovascular disease and stroke, the authors assessed baseline MS (defined according to International Diabetic Federation Criteria). Cognitive decline was predefined as at least 2-point drop in MMSE score at follow-up 1-2 years after baseline assessment. RESULTS: MS was present in 26.3% of the participants at baseline and was significantly associated with the risk of cognitive decline (odds ratio, 1.42: confidence interval, 1.01-1.98), after controlling for potential confounding by age, gender, education, smoking, alcohol drinking, depressive symptoms, APOE-e4 status, level of leisure activities, baseline MMSE, and length of follow-up. CONCLUSION: The MS was associated with increased risk of cognitive decline in Chinese older adults.
OBJECTIVE: To determine the association of the metabolic syndrome (MS) with cognitive decline in a Chinese older population. METHODS: In a prospective cohort study of 1,352 community-living Chinese older adults without cognitive impairment (Mini Mental State Examination, MMSE <24) and without cardiovascular disease and stroke, the authors assessed baseline MS (defined according to International Diabetic Federation Criteria). Cognitive decline was predefined as at least 2-point drop in MMSE score at follow-up 1-2 years after baseline assessment. RESULTS: MS was present in 26.3% of the participants at baseline and was significantly associated with the risk of cognitive decline (odds ratio, 1.42: confidence interval, 1.01-1.98), after controlling for potential confounding by age, gender, education, smoking, alcohol drinking, depressive symptoms, APOE-e4 status, level of leisure activities, baseline MMSE, and length of follow-up. CONCLUSION: The MS was associated with increased risk of cognitive decline in Chinese older adults.
Authors: Jean H Kim; Timothy S Sumerlin; William B Goggins; Elizabeth M S Kwong; Jason Leung; Blanche Yu; Timothy C Y Kwok Journal: Am J Geriatr Psychiatry Date: 2021-01-23 Impact factor: 4.105
Authors: Virginia G Wadley; Frederick W Unverzagt; Lisa C McGuire; Claudia S Moy; Rodney Go; Brett Kissela; Leslie A McClure; Michael Crowe; Virginia J Howard; George Howard Journal: Ann Neurol Date: 2011-05-26 Impact factor: 10.422