Literature DB >> 18515314

Kisspeptin and KISS1R: a critical pathway in the reproductive system.

Elena Gianetti1, Stephanie Seminara.   

Abstract

In 2003, three groups around the world simultaneously discovered that KISS1R (GPR54) is a key gatekeeper of sexual maturation in both mice and men. Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of GNRH-induced gonadotropin secretion and may modulate both positive and negative sex steroid feedback effects at the hypothalamic level. Genetic studies in humans have revealed both loss-of-function and gainof-function mutations in patients with idiopathic hypogonadotropic hypogonadism and precocious puberty respectively. This review examines the kisspeptin/KISS1R pathway in the reproductive system.

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Year:  2008        PMID： 18515314      PMCID： PMC2858313          DOI： 10.1530/REP-08-0091

Source DB:  PubMed          Journal:  Reproduction        ISSN： 1470-1626            Impact factor:   3.906


  70 in total

1.  Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54.

Authors:  J Carl Pallais; Yousef Bo-Abbas; Nelly Pitteloud; William F Crowley; Stephanie B Seminara
Journal:  Mol Cell Endocrinol       Date:  2006-06-06       Impact factor: 4.102

2.  Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats.

Authors:  Juan M Castellano; Victor M Navarro; Rafael Fernández-Fernández; Juan Roa; Eva Vigo; Rafael Pineda; Carlos Dieguez; Enrique Aguilar; Leonor Pinilla; Manuel Tena-Sempere
Journal:  Diabetes       Date:  2006-09       Impact factor: 9.461

3.  Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

Authors:  Sophie Messager; Emmanouella E Chatzidaki; Dan Ma; Alan G Hendrick; Dirk Zahn; John Dixon; Rosemary R Thresher; Isabelle Malinge; Didier Lomet; Mark B L Carlton; William H Colledge; Alain Caraty; Samuel A J R Aparicio
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-21       Impact factor: 11.205

4.  The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.

Authors:  M Kotani; M Detheux; A Vandenbogaerde; D Communi; J M Vanderwinden; E Le Poul; S Brézillon; R Tyldesley; N Suarez-Huerta; F Vandeput; C Blanpain; S N Schiffmann; G Vassart; M Parmentier
Journal:  J Biol Chem       Date:  2001-07-16       Impact factor: 5.157

5.  Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.

Authors:  T Ohtaki; Y Shintani; S Honda; H Matsumoto; A Hori; K Kanehashi; Y Terao; S Kumano; Y Takatsu; Y Masuda; Y Ishibashi; T Watanabe; M Asada; T Yamada; M Suenaga; C Kitada; S Usuki; T Kurokawa; H Onda; O Nishimura; M Fujino
Journal:  Nature       Date:  2001-05-31       Impact factor: 49.962

6.  AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.

Authors:  A I Muir; L Chamberlain; N A Elshourbagy; D Michalovich; D J Moore; A Calamari; P G Szekeres; H M Sarau; J K Chambers; P Murdock; K Steplewski; U Shabon; J E Miller; S E Middleton; J G Darker; C G Larminie; S Wilson; D J Bergsma; P Emson; R Faull; K L Philpott; D C Harrison
Journal:  J Biol Chem       Date:  2001-05-31       Impact factor: 5.157

7.  Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23.

Authors:  F Shirasaki; M Takata; N Hatta; K Takehara
Journal:  Cancer Res       Date:  2001-10-15       Impact factor: 12.701

8.  Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism.

Authors:  Felecia Cerrato; Jenna Shagoury; Milena Kralickova; Andrew Dwyer; John Falardeau; Metin Ozata; Guy Van Vliet; Pierre Bouloux; Janet E Hall; Frances J Hayes; Nelly Pitteloud; Kathryn A Martin; Corrine Welt; Stephanie B Seminara
Journal:  Eur J Endocrinol       Date:  2006-11       Impact factor: 6.664

9.  Continuous human metastin 45-54 infusion desensitizes G protein-coupled receptor 54-induced gonadotropin-releasing hormone release monitored indirectly in the juvenile male Rhesus monkey (Macaca mulatta): a finding with therapeutic implications.

Authors:  Stephanie B Seminara; Meloni J Dipietro; Suresh Ramaswamy; William F Crowley; Tony M Plant
Journal:  Endocrinology       Date:  2006-02-09       Impact factor: 4.736

Review 10.  The neuroendocrinology of human puberty revisited.

Authors:  Melvin M Grumbach
Journal:  Horm Res       Date:  2002
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  14 in total

Review 1.  International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function.

Authors:  Helen R Kirby; Janet J Maguire; William H Colledge; Anthony P Davenport
Journal:  Pharmacol Rev       Date:  2010-12       Impact factor: 25.468

2.  Double-blind, randomized, placebo-controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-683, an investigational metastin analogue in healthy men.

Authors:  Graham Scott; Irfan Ahmad; Katy Howard; David MacLean; Cristina Oliva; Steve Warrington; Darren Wilbraham; Paul Worthington
Journal:  Br J Clin Pharmacol       Date:  2013-02       Impact factor: 4.335

3.  Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women.

Authors:  Alexander Kucherov; Alex J Polotsky; Marie Menke; Barbara Isaac; Beth McAvey; Erkan Buyuk; Andrew P Bradford; Cheryl Hickmon; Beatrice Babbs; Sarah Berga; Tammy Loucks; Nanette Santoro
Journal:  Fertil Steril       Date:  2011-02-26       Impact factor: 7.329

Review 4.  Metastasis suppressor genes at the interface between the environment and tumor cell growth.

Authors:  Douglas R Hurst; Danny R Welch
Journal:  Int Rev Cell Mol Biol       Date:  2011       Impact factor: 6.813

5.  Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.

Authors:  Qi Wu; Benjamin B Whiddon; Richard D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-09       Impact factor: 11.205

Review 6.  The KISS1 metastasis suppressor: a good night kiss for disseminated cancer cells.

Authors:  Benjamin H Beck; Danny R Welch
Journal:  Eur J Cancer       Date:  2010-03-19       Impact factor: 9.162

Review 7.  Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model.

Authors:  Bailey A Kermath; Andrea C Gore
Journal:  Neuroendocrinology       Date:  2012-02-17       Impact factor: 4.914

8.  TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

Authors:  A Kemal Topaloglu; Frank Reimann; Metin Guclu; Ayse Serap Yalin; L Damla Kotan; Keith M Porter; Ayse Serin; Neslihan O Mungan; Joshua R Cook; Sazi Imamoglu; N Sema Akalin; Bilgin Yuksel; Stephen O'Rahilly; Robert K Semple
Journal:  Nat Genet       Date:  2008-12-11       Impact factor: 38.330

Review 9.  Kisspeptin signaling in the brain.

Authors:  Amy E Oakley; Donald K Clifton; Robert A Steiner
Journal:  Endocr Rev       Date:  2009-09-21       Impact factor: 19.871

10.  Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution.

Authors:  Ronald Shin; Danny R Welch; Vinod K Mishra; Kevin T Nash; Douglas R Hurst; N Rama Krishna
Journal:  Clin Exp Metastasis       Date:  2009-03-24       Impact factor: 5.150
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