BACKGROUND: The standard test for diagnosing Barrett's esophagus (BE) is a conventional upper endoscopy. However, studies have shown that confirmation of BE by endoscopy with histologic intestinal metaplasia can be difficult. OBJECTIVE: To determine the overall accuracy, as well as factors that influence the accuracy of a conventional upper endoscopy in diagnosing BE. SETTING: Thirteen academic, community, and Veterans Affairs sites. DESIGN: A retrospective data review. PATIENTS: Patients who underwent an upper endoscopy with a finding of "suspected Barrett's esophagus" and esophageal biopsies. Pathology reports were examined to identify cases with intestinal metaplasia. MAIN OUTCOME MEASUREMENTS: Percentage of pathology-confirmed BE among suspected cases. RESULTS: A total of 2511 procedures were examined; the frequency of biopsy-confirmed BE was 48.4%. Multivariate logistic regression identified the following factors to be independently associated with biopsy-confirmed BE: long-segment BE that measured > or = 3 cm (odds ratio [OR] 4.61 [95% CI, 3.73-5.69]), male sex (OR 1.82 [95% CI, 1.49-2.22]), increasing age (age interval 70-79 years with OR 2.33 compared with age <50 years [95% CI, 1.75-3.10]), the presence of a hiatal hernia (OR 1.46 [95% CI, 1.22-1.84]), and white race (OR 1.90 [95% CI, 1.49-2.22]). LIMITATIONS: Biopsy specimens were assumed to sample the tubular esophagus; the actual pathology slides were not reevaluated by the investigators. CONCLUSIONS: Endoscopic evaluation has limitations for the diagnosis of BE. Specific patient and endoscopic characteristics may be associated with the confirmation of BE on biopsy specimens. Further study is needed to determine if new endoscopic imaging technologies improve the ability to correctly identify BE.
BACKGROUND: The standard test for diagnosing Barrett's esophagus (BE) is a conventional upper endoscopy. However, studies have shown that confirmation of BE by endoscopy with histologic intestinal metaplasia can be difficult. OBJECTIVE: To determine the overall accuracy, as well as factors that influence the accuracy of a conventional upper endoscopy in diagnosing BE. SETTING: Thirteen academic, community, and Veterans Affairs sites. DESIGN: A retrospective data review. PATIENTS: Patients who underwent an upper endoscopy with a finding of "suspected Barrett's esophagus" and esophageal biopsies. Pathology reports were examined to identify cases with intestinal metaplasia. MAIN OUTCOME MEASUREMENTS: Percentage of pathology-confirmed BE among suspected cases. RESULTS: A total of 2511 procedures were examined; the frequency of biopsy-confirmed BE was 48.4%. Multivariate logistic regression identified the following factors to be independently associated with biopsy-confirmed BE: long-segment BE that measured > or = 3 cm (odds ratio [OR] 4.61 [95% CI, 3.73-5.69]), male sex (OR 1.82 [95% CI, 1.49-2.22]), increasing age (age interval 70-79 years with OR 2.33 compared with age <50 years [95% CI, 1.75-3.10]), the presence of a hiatal hernia (OR 1.46 [95% CI, 1.22-1.84]), and white race (OR 1.90 [95% CI, 1.49-2.22]). LIMITATIONS: Biopsy specimens were assumed to sample the tubular esophagus; the actual pathology slides were not reevaluated by the investigators. CONCLUSIONS: Endoscopic evaluation has limitations for the diagnosis of BE. Specific patient and endoscopic characteristics may be associated with the confirmation of BE on biopsy specimens. Further study is needed to determine if new endoscopic imaging technologies improve the ability to correctly identify BE.
Authors: Jukka Ronkainen; Pertti Aro; Tom Storskrubb; Sven-Erik Johansson; Tore Lind; Elisabeth Bolling-Sternevald; Michael Vieth; Manfred Stolte; Nicholas J Talley; Lars Agréus Journal: Gastroenterology Date: 2005-12 Impact factor: 22.682
Authors: Brenda Westhoff; Scott Brotze; Allan Weston; Christian McElhinney; Rachel Cherian; Matthew S Mayo; Holly J Smith; Prateek Sharma Journal: Gastrointest Endosc Date: 2005-02 Impact factor: 9.427
Authors: S L Kim; J P Waring; S J Spechler; R E Sampliner; W G Doos; W F Krol; W O Williford Journal: Gastroenterology Date: 1994-10 Impact factor: 22.682
Authors: E Endlicher; P Rümmele; S Beer; R Knüchel; H Rath; K Schlottmann; J Grossmann; U Woenckhaus; J Schölmerich; H Messmann Journal: Endoscopy Date: 2005-11 Impact factor: 10.093
Authors: Alexander C Ford; David Forman; P Dominic Reynolds; Brian T Cooper; Paul Moayyedi Journal: Am J Epidemiol Date: 2005-08-02 Impact factor: 4.897
Authors: Melissa J Suter; Michalina J Gora; Gregory Y Lauwers; Thomas Arnason; Jenny Sauk; Kevin A Gallagher; Lauren Kava; Khay M Tan; Amna R Soomro; Timothy P Gallagher; Joseph A Gardecki; Brett E Bouma; Mireille Rosenberg; Norman S Nishioka; Guillermo J Tearney Journal: Gastrointest Endosc Date: 2014-01-23 Impact factor: 9.427