Literature DB >> 1851362

Polyneuropathy associated with IgA monoclonal gammopathy: a hypothesis of its pathogenesis.

R Nemni1, A Mamoli, R Fazio, M Camerlingo, A Quattrini, I Lorenzetti, M Comola, G Galardi, N Canal.   

Abstract

We describe three patients with chronic progressive polyneuropathy associated with IgA monoclonal gammopathy. Two patients had a prominent sensory neuropathy and one had a prominent motor neuropathy. Sural nerve biopsies showed axonal degeneration in all cases. In immunocytochemical studies patients' IgG immunostained axons. By Western immunoblot a band of IgG reactivity with an axonal protein of 66 kDa was found. No band of IgA and IgM were found. We suggest the possibility that the IgA monoclonal protein may act as a stimulating factor of preexisting B cell clones eliciting an immune reaction against nerve antigens.

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Year:  1991        PMID： 1851362     DOI： 10.1007/bf00293456

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  27 in total

1.  Distribution of albumin-like immunoreactivity in rat sciatic nerve after nerve crush injury.

Authors:  M Mata; J Staple; D J Fink
Journal:  J Neuropathol Exp Neurol       Date:  1988-05       Impact factor: 3.685

2.  Regulation of B cell maturation and differentiation. I. Suppression of pokeweed mitogen-induced B cell differentiation by tumor necrosis factor (TNF).

Authors:  H Kashiwa; S C Wright; B Bonavida
Journal:  J Immunol       Date:  1987-03-01       Impact factor: 5.422

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Protein composition of axons and myelin from rat and human peripheral nerves.

Authors:  S Micko; W W Schlaepfer
Journal:  J Neurochem       Date:  1978-05       Impact factor: 5.372

5.  Human B cell differentiation by Fc fragment. III. Effect of IL-1 and IL-2 on differentiation of human B lymphocytes induced by Fc fragments of human IgG.

Authors:  E D Carosella; A B Tilden; N E Dunlap
Journal:  Cell Immunol       Date:  1989-07       Impact factor: 4.868

6.  Antibodies to human spinal cord proteins in sera from patients with motor neuron disease and other neurological diseases.

Authors:  T Inuzuka; S Sato; K Yanagisawa; T Miyatake
Journal:  Eur Neurol       Date:  1989       Impact factor: 1.710

7.  Monoclonal IgM kappa antibody precipitating with chondroitin sulfate C from patients with axonal polyneuropathy and epidermolysis.

Authors:  W H Sherman; N Latov; A P Hays; M Takatsu; R Nemni; G Galassi; E F Osserman
Journal:  Neurology       Date:  1983-02       Impact factor: 9.910

8.  Polyneuropathy with monoclonal gammopathy: glycolipids are frequently antigens for IgM paraproteins.

Authors:  A A Ilyas; R H Quarles; M C Dalakas; R O Brady
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

9.  Monoclonal anti-DNA IgM kappa in neuropathy binds to myelin and to a conformational epitope formed by phosphatidic acid and gangliosides.

Authors:  L Freddo; A P Hays; K G Nickerson; L Spatz; S McGinnis; R Lieberson; C A Vedeler; M E Shy; L Autilio-Gambetti; F C Grauss
Journal:  J Immunol       Date:  1986-12-15       Impact factor: 5.422

10.  Demyelinating polyneuropathy associated with monoclonal IgM-paraproteinaemia. Histological, ultrastructural and immunocytochemical studies.

Authors:  C Meier; M Vandevelde; A Steck; A Zurbriggen
Journal:  J Neurol Sci       Date:  1984-03       Impact factor: 3.181
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