BACKGROUND: The presence of oxygen is necessary for normal wound healing. Oxygen has been given as a therapeutic modality to assist and speed wound healing. OBJECTIVE: The objective was to summarize the role of oxygen in wound healing. MATERIALS AND METHODS: A literature review of clinical and basic science studies regarding oxygen and wound healing was conducted. RESULTS: Hypoxia appears to jump start wound healing via hypoxia-inducible factor 1alpha and reepithelialization. Nonetheless, oxygen is often required to start or sustain other wound healing processes. CONCLUSION: Both the absence and the presence of oxygen have effects on wound healing; however, its role is not completely understood. Although hyperbaric oxygen and topical oxygen therapy have been described in aiding wound healing, case-controlled prospective studies are lacking and evidence for their efficacy is inconsistent. The authors have indicated no significant interest with commercial supporters.
BACKGROUND: The presence of oxygen is necessary for normal wound healing. Oxygen has been given as a therapeutic modality to assist and speed wound healing. OBJECTIVE: The objective was to summarize the role of oxygen in wound healing. MATERIALS AND METHODS: A literature review of clinical and basic science studies regarding oxygen and wound healing was conducted. RESULTS:Hypoxia appears to jump start wound healing via hypoxia-inducible factor 1alpha and reepithelialization. Nonetheless, oxygen is often required to start or sustain other wound healing processes. CONCLUSION: Both the absence and the presence of oxygen have effects on wound healing; however, its role is not completely understood. Although hyperbaric oxygen and topical oxygen therapy have been described in aiding wound healing, case-controlled prospective studies are lacking and evidence for their efficacy is inconsistent. The authors have indicated no significant interest with commercial supporters.
Authors: Lohrasb R Sayadi; Derek A Banyard; Mary E Ziegler; Zaidal Obagi; Jordyne Prussak; Michael J Klopfer; Gregory Rd Evans; Alan D Widgerow Journal: Int Wound J Date: 2018-01-05 Impact factor: 3.315
Authors: Wan Xing Hong; Michael S Hu; Mikaela Esquivel; Grace Y Liang; Robert C Rennert; Adrian McArdle; Kevin J Paik; Dominik Duscher; Geoffrey C Gurtner; H Peter Lorenz; Michael T Longaker Journal: Adv Wound Care (New Rochelle) Date: 2014-05-01 Impact factor: 4.730
Authors: Alma N Olivieri; Antonio Mellos; Carlo Duilio; Milena Di Meglio; Angela Mauro; Laura Perrone Journal: Ital J Pediatr Date: 2010-10-31 Impact factor: 2.638