Literature DB >> 18511958

A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.

Lukasz P Słomnicki1, Wiesława Leśniak.   

Abstract

Amyloid Precursor Protein (APP) Intracellular Domain (AICD) is the product of APP processing realized by alpha- or beta-secretases and gamma-secretase. It was shown that AICD is able to interact with several proteins which regulate its stability and cellular localization. The Fe65 adaptor protein translocates AICD into nucleus where the APP-Fe65-Tip60 ternary complex may activate transcription of target genes. In the light of recent studies AICD seems to be another product of APP proteolysis endowed with important biological functions that may contribute to Alzheimer's disease pathology.

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Year:  2008        PMID： 18511958

Source DB:  PubMed          Journal:  Acta Neurobiol Exp (Wars)        ISSN： 0065-1400            Impact factor:   1.579


  24 in total

Review 1.  γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.

Authors:  Kohzo Nakayama; Hisashi Nagase; Chang-Sung Koh; Takeshi Ohkawara
Journal:  Cell Mol Neurobiol       Date:  2011-04-23       Impact factor: 5.046

2.  Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes.

Authors:  Wulin Yang; Amy Yong Chen Lau; Shuizhong Luo; Qian Zhu; Li Lu
Journal:  Neurosci Bull       Date:  2012-06       Impact factor: 5.203

Review 3.  The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease.

Authors:  Yanuar Alan Sulistio; Klaus Heese
Journal:  Mol Neurobiol       Date:  2015-01-07       Impact factor: 5.590

4.  APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.

Authors:  Dana M Niedowicz; Tina L Beckett; Chris J Holler; Adam M Weidner; M Paul Murphy
Journal:  Neurosci Lett       Date:  2010-07-16       Impact factor: 3.046

5.  Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model.

Authors:  Sheila K Pirooznia; Jessica Sarthi; Ashley A Johnson; Meridith S Toth; Kellie Chiu; Sravanthi Koduri; Felice Elefant
Journal:  PLoS One       Date:  2012-07-26       Impact factor: 3.240

6.  Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.

Authors:  Ashley A Johnson; Jessica Sarthi; Sheila K Pirooznia; William Reube; Felice Elefant
Journal:  J Neurosci       Date:  2013-04-24       Impact factor: 6.167

Review 7.  Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.

Authors:  Gerhard Multhaup; Otmar Huber; Luc Buée; Marie-Christine Galas
Journal:  J Biol Chem       Date:  2015-08-21       Impact factor: 5.157

Review 8.  Motifs and interface amino acid-mediated regulation of amyloid biogenesis in microbes to humans: potential targets for intervention.

Authors:  Ayesha Z Beg; Asad U Khan
Journal:  Biophys Rev       Date:  2020-09-15

9.  Organization of amyloid-beta protein precursor intracellular domain-associated protein-1 in the rat brain.

Authors:  Amanda L Jacob; Bryen A Jordan; Richard J Weinberg
Journal:  J Comp Neurol       Date:  2010-08-15       Impact factor: 3.215

Review 10.  Pharmacology of epigenetics in brain disorders.

Authors:  Pritika Narayan; Mike Dragunow
Journal:  Br J Pharmacol       Date:  2009-12-15       Impact factor: 8.739
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