BACKGROUND: The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort. METHODS: Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences. RESULTS: No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers. CONCLUSIONS: In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.
BACKGROUND: The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort. METHODS: Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences. RESULTS: No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers. CONCLUSIONS: In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.
Authors: Jessica M Foley; David H Salat; Nikki H Stricker; Tyler A Zink; Laura J Grande; Regina E McGlinchey; William P Milberg; Elizabeth C Leritz Journal: Am J Alzheimers Dis Other Demen Date: 2013-12-31 Impact factor: 2.035
Authors: Steven G Potkin; Guia Guffanti; Anita Lakatos; Jessica A Turner; Frithjof Kruggel; James H Fallon; Andrew J Saykin; Alessandro Orro; Sara Lupoli; Erika Salvi; Michael Weiner; Fabio Macciardi Journal: PLoS One Date: 2009-08-07 Impact factor: 3.240
Authors: Jessica M Foley; David H Salat; Nikki H Stricker; Regina E McGlinchey; William P Milberg; Laura J Grande; Elizabeth C Leritz Journal: Am J Alzheimers Dis Other Demen Date: 2015-05-24 Impact factor: 2.035
Authors: Owen A Williams; Yang An; Lori Beason-Held; Yuankai Huo; Luigi Ferrucci; Bennett A Landman; Susan M Resnick Journal: Neuroimage Date: 2018-12-15 Impact factor: 6.556
Authors: Markus Donix; Alison C Burggren; Nanthia A Suthana; Prabha Siddarth; Arne D Ekstrom; Allison K Krupa; Michael Jones; Anup Rao; Laurel Martin-Harris; Linda M Ercoli; Karen J Miller; Gary W Small; Susan Y Bookheimer Journal: Neuroimage Date: 2010-06-10 Impact factor: 6.556
Authors: Ivar Reinvang; Ian J Deary; Anders M Fjell; Vidar M Steen; Thomas Espeseth; Raja Parasuraman Journal: Front Aging Neurosci Date: 2010-11-02 Impact factor: 5.750
Authors: Martin A Ystad; Astri J Lundervold; Eike Wehling; Thomas Espeseth; Helge Rootwelt; Lars Tjelta Westlye; Martin Andersson; Steinunn Adolfsdottir; Jonn Terje Geitung; Anders M Fjell; Ivar Reinvang; Arvid Lundervold Journal: BMC Med Imaging Date: 2009-08-22 Impact factor: 1.930