OBJECTIVES: We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects. METHODS: Participants aged 50 to 70 years (N=1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and (109)Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations. RESULTS: Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) mug/dL, 18.9 (12.5) mug/g, and 6.8 (18.1) mug/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P < .01). We observed effect modification by race/ethnicity on the association of gender and physical activity to blood lead concentrations and by gender on the association of age to tibia lead concentrations. Patella lead concentrations differed by gender; apolipoprotein E genotype modified this relation. CONCLUSIONS: African Americans evidenced a prominent disparity in lifetime lead dose. Women may be at higher risk of release of lead from bone and consequent health effects because of increased bone demineralization with aging.
OBJECTIVES: We sought to identify predictors of lead concentrations in the blood, tibias, and patellae of older adults and to describe differences by gender, race/ethnicity, and other factors that can influence lead toxicokinetics and, thus modify health effects. METHODS:Participants aged 50 to 70 years (N=1140) were randomly identified from selected neighborhoods in Baltimore, Maryland. We measured lead concentrations by anodic stripping voltammetry (in blood) and (109)Cd-induced K-shell x-ray fluorescence (in bone). We used multiple linear regression to identify predictors of lead concentrations. RESULTS: Mean (SD) lead concentrations in blood, tibias, and patellae were 3.5 (2.4) mug/dL, 18.9 (12.5) mug/g, and 6.8 (18.1) mug/g, respectively. Tibia concentrations were 29% higher in African Americans than in Whites (P < .01). We observed effect modification by race/ethnicity on the association of gender and physical activity to blood lead concentrations and by gender on the association of age to tibia lead concentrations. Patella lead concentrations differed by gender; apolipoprotein E genotype modified this relation. CONCLUSIONS: African Americans evidenced a prominent disparity in lifetime lead dose. Women may be at higher risk of release of lead from bone and consequent health effects because of increased bone demineralization with aging.
Authors: M J Brown; H Hu; T Gonzales-Cossio; K E Peterson; L H Sanin; M de Luz Kageyama; E Palazuelos; A Aro; L Schnaas; M Hernandez-Avila Journal: Occup Environ Med Date: 2000-08 Impact factor: 4.402
Authors: Sahar F Elmarsafawy; Shirng-Wern Tsaih; Susan Korrick; Jefferson H Dickey; David Sparrow; Antonio Aro; Howard Hu Journal: Am J Ind Med Date: 2002-07 Impact factor: 2.214
Authors: Susan A Korrick; Joel Schwartz; Shirng-Wern Tsaih; David J Hunter; Antonio Aro; Bernard Rosner; Frank E Speizer; Howard Hu Journal: Am J Epidemiol Date: 2002-08-15 Impact factor: 4.897
Authors: Brian S Schwartz; Brian Caffo; Walter F Stewart; Haley Hedlin; Bryan D James; David Yousem; Christos Davatzikos Journal: J Occup Environ Med Date: 2010-04 Impact factor: 2.162
Authors: Xin Wang; Bhramar Mukherjee; Stuart Batterman; Siobán D Harlow; Sung Kyun Park Journal: Int J Hyg Environ Health Date: 2019-05-15 Impact factor: 5.840
Authors: Christine Neslund-Dudas; Albert M Levin; Andrew Rundle; Jennifer Beebe-Dimmer; Cathryn H Bock; Nora L Nock; Michelle Jankowski; Indrani Datta; Richard Krajenta; Q Ping Dou; Bharati Mitra; Deliang Tang; Benjamin A Rybicki Journal: Prostate Date: 2014-02-05 Impact factor: 4.104
Authors: Maryse F Bouchard; David C Bellinger; Jennifer Weuve; Julia Matthews-Bellinger; Stephen E Gilman; Robert O Wright; Joel Schwartz; Marc G Weisskopf Journal: Arch Gen Psychiatry Date: 2009-12
Authors: Sung Kyun Park; Bhramar Mukherjee; Xi Xia; David Sparrow; Marc G Weisskopf; Huiling Nie; Howard Hu Journal: J Occup Environ Med Date: 2009-12 Impact factor: 2.162
Authors: Marie Lynn Miranda; Sharon E Edwards; Geeta K Swamy; Christopher J Paul; Brian Neelon Journal: Int J Environ Res Public Health Date: 2010-04-01 Impact factor: 3.390