| Literature DB >> 18511278 |
Daqing Sun1, Zhulun Wang, Yongmei Di, Juan C Jaen, Marc Labelle, Ji Ma, Shichang Miao, Athena Sudom, Liang Tang, Craig S Tomooka, Hua Tu, Stefania Ursu, Nigel Walker, Xuelei Yan, Qiuping Ye, Jay P Powers.
Abstract
High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11beta-Hydroxysteroid Dehydrogenase Type 1 (11beta-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11beta-HSD1 IC(50)=3nM).Entities:
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Year: 2008 PMID： 18511278 DOI： 10.1016/j.bmcl.2008.05.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823