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Literature DB >> 18510362

Bioactive isocoumarins isolated from the endophytic fungus Microdochium bolleyi.

Wen Zhang¹, Karsten Krohn, Siegfried Draeger, Barbara Schulz.

Abstract

Three new isocoumarin derivatives ( 2- 4) were isolated together with monocerin ( 1) from Microdochium bolleyi, an endophytic fungus from Fagonia cretica, a herbaceous plant of the semiarid coastal regions of Gomera. Compounds 2 and 3 are both 12-oxo epimers of 1, and 4 is a ring-opened derivative of 1. The structures were elucidated by detailed spectroscopic analysis and comparison with reported data. The absolute configurations were determined by a modified Mosher's method. Compounds 1, 3, and 4 showed good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca. Compound 2 was moderately antifungal and antialgal.

Entities: Chemical Species

Mesh：

Substances：

Year: 2008 PMID： 18510362 DOI： 10.1021/np800095g

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

16 in total

1. Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl.

Authors: Iara F Santiago; Tânia M A Alves; Ana Rabello; Policarpo A Sales Junior; Alvaro J Romanha; Carlos L Zani; Carlos A Rosa; Luiz H Rosa
Journal: Extremophiles Date: 2011-11-10 Impact factor: 2.395

2. Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp. KcF6.

Authors: Zhiran Ju; Xiuping Lin; Xin Lu; Zhengchao Tu; Junfeng Wang; Kumaravel Kaliyaperumal; Juan Liu; Yongqi Tian; Shihai Xu; Yonghong Liu
Journal: J Antibiot (Tokyo) Date: 2015-05-13 Impact factor: 2.649

3. Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source.

Authors: Eric M Woerly; Steven M Banik; Eric N Jacobsen
Journal: J Am Chem Soc Date: 2016-10-13 Impact factor: 15.419

4. Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties.

Authors: Arun K Ghosh; Daniel S Lee
Journal: J Org Chem Date: 2019-04-29 Impact factor: 4.354

Review 5. Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities.

Authors: Ahmad Omar Noor; Diena Mohammedallam Almasri; Alaa Abdullah Bagalagel; Hossam Mohamed Abdallah; Shaimaa Gamal Abdallah Mohamed; Gamal Abdallah Mohamed; Sabrin Ragab Mohamed Ibrahim
Journal: Molecules Date: 2020-01-17 Impact factor: 4.411

10. Silica sulfuric acid: a reusable solid catalyst for one pot synthesis of densely substituted pyrrole-fused isocoumarins under solvent-free conditions.

Authors: Sudipta Pathak; Kamalesh Debnath; Animesh Pramanik
Journal: Beilstein J Org Chem Date: 2013-11-04 Impact factor: 2.883

Bioactive isocoumarins isolated from the endophytic fungus Microdochium bolleyi.

1. Leishmanicidal and antitumoral activities of endophytic fungi associated with the Antarctic angiosperms Deschampsia antarctica Desv. and Colobanthus quitensis (Kunth) Bartl.

2. Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp. KcF6.

3. Enantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source.

4. Enantioselective Total Synthesis of (+)-Monocerin, a Dihydroisocoumarin Derivative with Potent Antimalarial Properties.

Review 5. Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities.

6. Cytotoxic and apoptosis-inducing effects of novel 8-amido isocoumarin derivatives against breast cancer cells.

7. New substituted isocoumarins and Dihydroisocoumarins and their cytotoxic activities.

8. Synthesis and biological evaluation of some novel 3,4-disubstituted isocoumarins.

Review 9. Endophytic fungi: a reservoir of antibacterials.

10. Silica sulfuric acid: a reusable solid catalyst for one pot synthesis of densely substituted pyrrole-fused isocoumarins under solvent-free conditions.