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Literature DB >> 18509762

Maxadilan, the PAC1 receptor, and leishmaniasis.

Vemuri B Reddy¹, Yhong Li, Ethan A Lerner.

Abstract

Maxadilan is a vasodilator peptide isolated from sand fly salivary glands. The vasodilator effects of maxadilan are mediated by the PAC1 receptor, although maxadilan and PACAP do not share sequence homology. Sand flies are the vector of the parasitic disease leishmaniasis. The peptide aids the sand fly in obtaining a blood meal while enhancing the infectivity of leishmania parasites transmitted by this arthropod vector. Aspects of maxadilan, PAC1, and leishmaniasis are discussed.

Entities: Disease Gene

Mesh：

Substances：

Year: 2008 PMID： 18509762 DOI： 10.1007/s12031-008-9079-1

Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444

25 in total

1. Receptors for the vasodilator maxadilan are expressed on selected neural crest and smooth muscle-derived cells.

Authors: O Moro; M Tajima; E A Lerner
Journal: Insect Biochem Mol Biol Date: 1996-12 Impact factor: 4.714

2. Regulation of atrial natriuretic peptide secretion by cholinergic and PACAP neurons of the gastric antrum.

Authors: William R Gower; John R Dietz; Robert W McCuen; Peter J Fabri; Ethan A Lerner; Mitchell L Schubert
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2003-01 Impact factor: 4.052

3. The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor.

Authors: M B Soares; R G Titus; C B Shoemaker; J R David; M Bozza
Journal: J Immunol Date: 1998-02-15 Impact factor: 5.422

4. Vasorelaxant and second messenger effects of maxadilan.

Authors: S A Grevelink; J Osborne; J Loscalzo; E A Lerner
Journal: J Pharmacol Exp Ther Date: 1995-01 Impact factor: 4.030

5. Functional characterization of structural alterations in the sequence of the vasodilatory peptide maxadilan yields a pituitary adenylate cyclase-activating peptide type 1 receptor-specific antagonist.

Authors: O Moro; K Wakita; M Ohnuma; S Denda; E A Lerner; M Tajima
Journal: J Biol Chem Date: 1999-08-13 Impact factor: 5.157

6. Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice.

Authors: C M Theodos; J M Ribeiro; R G Titus
Journal: Infect Immun Date: 1991-05 Impact factor: 3.441

7. Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis.

Authors: A Warburg; E Saraiva; G C Lanzaro; R G Titus; F Neva
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1994-07-29 Impact factor: 6.237

8. Immunomodulatory properties of maxadilan, the vasodilator peptide from sand fly salivary gland extracts.

Authors: A A Qureshi; A Asahina; M Ohnuma; M Tajima; R D Granstein; E A Lerner
Journal: Am J Trop Med Hyg Date: 1996-06 Impact factor: 2.345

9. PACAP promotes neural stem cell proliferation in adult mouse brain.

Authors: Alex Mercer; Harriet Rönnholm; Johan Holmberg; Hanna Lundh; Jessica Heidrich; Olof Zachrisson; Amina Ossoinak; Jonas Frisén; Cesare Patrone
Journal: J Neurosci Res Date: 2004-04-15 Impact factor: 4.164

10. Maxadilan binds to membrane fractions of brain tissue.

Authors: O Moro; T J Tsomides; M Tajima; E A Lerner
Journal: Biochem Biophys Res Commun Date: 1995-11-02 Impact factor: 3.575

4 in total

1. Members of the salivary gland surface protein (SGS) family are major immunogenic components of mosquito saliva.

Authors: Jonas G King; Kenneth D Vernick; Julián F Hillyer
Journal: J Biol Chem Date: 2011-09-29 Impact factor: 5.157

2. CART peptide stimulation of G protein-mediated signaling in differentiated PC12 cells: identification of PACAP 6-38 as a CART receptor antagonist.

Authors: Yiming Lin; Randy A Hall; Michael J Kuhar
Journal: Neuropeptides Date: 2011-08-19 Impact factor: 3.286

3. Update in the treatment of cutaneous leishmaniasis.

Authors: Sahar H Al-Natour
Journal: J Family Community Med Date: 2009-05

4. Immunization against full-length protein and peptides from the Lutzomyia longipalpis sand fly salivary component maxadilan protects against Leishmania major infection in a murine model.

Authors: William H Wheat; Erik N Arthun; John S Spencer; Daniel P Regan; Richard G Titus; Steven W Dow
Journal: Vaccine Date: 2017-10-24 Impact factor: 3.641

4 in total