PURPOSE: We investigated the correlation between abnormal perfusion areas by computed tomography perfusion (CTP) study of hyperacute stroke patients and the final infarction areas after intraarterial catheter thrombolysis. MATERIALS AND METHODS: CTP study using the box-modulation transfer function (box-MTF) method based on the deconvolution analysis method was performed in 22 hyperacute stroke patients. Ischemic lesions were immediately treated with catheter thrombolysis after CTP study. Among them, nine patients with middle cerebral artery (MCA) occlusion were investigated regarding correlations of the size of the prolonged mean transit time (MTT) area, the decreased cerebral blood volume (CBV) area, and the final infarction area. RESULTS: Using the box-MTF method, the prolonged MTT area was almost identical to the final infarction area in the case of catheter thrombolysis failure. The decreased CBV areas resulted in infarction or hemorrhage, irrespective of the outcome of recanalization after catheter thrombolysis. CONCLUSION: The prolonged MTT areas, detected by the box-MTF method of CTP in hyperacute stroke patients, included the area of true prolonged MTT and the tracer delay. The prolonged MTT area was almost identical to the final infarction area when recanalization failed. We believe that a tracer delay area also indicates infarction in cases of thrombolysis failure.
PURPOSE: We investigated the correlation between abnormal perfusion areas by computed tomography perfusion (CTP) study of hyperacute strokepatients and the final infarction areas after intraarterial catheter thrombolysis. MATERIALS AND METHODS:CTP study using the box-modulation transfer function (box-MTF) method based on the deconvolution analysis method was performed in 22 hyperacute strokepatients. Ischemic lesions were immediately treated with catheter thrombolysis after CTP study. Among them, nine patients with middle cerebral artery (MCA) occlusion were investigated regarding correlations of the size of the prolonged mean transit time (MTT) area, the decreased cerebral blood volume (CBV) area, and the final infarction area. RESULTS: Using the box-MTF method, the prolonged MTT area was almost identical to the final infarction area in the case of catheter thrombolysis failure. The decreased CBV areas resulted in infarction or hemorrhage, irrespective of the outcome of recanalization after catheter thrombolysis. CONCLUSION: The prolonged MTT areas, detected by the box-MTF method of CTP in hyperacute strokepatients, included the area of true prolonged MTT and the tracer delay. The prolonged MTT area was almost identical to the final infarction area when recanalization failed. We believe that a tracer delay area also indicates infarction in cases of thrombolysis failure.
Authors: James D Eastwood; Michael H Lev; Tarek Azhari; Ting-Yim Lee; Daniel P Barboriak; David M Delong; Clemens Fitzek; Michael Herzau; Max Wintermark; Reto Meuli; David Brazier; James M Provenzale Journal: Radiology Date: 2002-01 Impact factor: 11.105
Authors: R Wirestam; L Andersson; L Ostergaard; M Bolling; J P Aunola; A Lindgren; B Geijer; S Holtås; F Ståhlberg Journal: Magn Reson Med Date: 2000-05 Impact factor: 4.668
Authors: Max Wintermark; Nancy J Fischbein; Wade S Smith; Nerissa U Ko; Marcel Quist; William P Dillon Journal: AJNR Am J Neuroradiol Date: 2005-01 Impact factor: 3.825
Authors: Pamela W Schaefer; George J Hunter; Julian He; Leena M Hamberg; A Gregory Sorensen; Lee H Schwamm; Walter J Koroshetz; R Gilberto Gonzalez Journal: AJNR Am J Neuroradiol Date: 2002 Nov-Dec Impact factor: 3.825