Literature DB >> 1850935

Human papillomavirus type 16 transcripts expressed from viral-cellular junctions and full-length viral copies in CaSki cells and in a cervical carcinoma.

H L Smits1, M T Cornelissen, M F Jebbink, J G van den Tweel, A P Struyk, M Briët, J ter Schegget.   

Abstract

We have mapped using the RNA PCR the viral-cellular junctions of HPV16 viral-cellular cotranscripts expressed in CaSki cells and a cervical carcinoma to nt 3728 and 881, respectively. Both junctions were located within the E1-E2 region. Examination of the cellular sequences of the cotranscripts showed the presence of a polyadenylation signal in each of the transcripts. In CaSki cells and in the cervical carcinoma transcripts derived from the full-length early region including the E2 transcript were also detected. Our results suggest that the utilization of a cellular polyadenylation site could be important in the development of cancer by HPV.

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Year:  1991        PMID： 1850935     DOI： 10.1016/0042-6822(91)90632-l

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  9 in total

1.  Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b.

Authors:  M A Ozbun; C Meyers
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

2.  Detection of human papillomavirus type 16 early-gene transcription by reverse transcription-PCR is associated with abnormal cervical cytology.

Authors:  C Biswas; B Kell; C Mant; R J Jewers; J Cason; P Muir; K S Raju; J M Best
Journal:  J Clin Microbiol       Date:  1997-06       Impact factor: 5.948

3.  Phenylbutyrate inhibits growth of cervical carcinoma cells independent of HPV type and copy number.

Authors:  P Finzer; M Stöhr; N Seibert; F Rösl
Journal:  J Cancer Res Clin Oncol       Date:  2003-02-27       Impact factor: 4.553

4.  Human Papillomavirus 16 Oncoprotein Expression Is Controlled by the Cellular Splicing Factor SRSF2 (SC35).

Authors:  Melanie McFarlane; Alasdair I MacDonald; Andrew Stevenson; Sheila V Graham
Journal:  J Virol       Date:  2015-02-25       Impact factor: 5.103

5.  Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.

Authors:  S Jeon; P F Lambert
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

6.  Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells.

Authors:  S Jeon; B L Allen-Hoffmann; P F Lambert
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

7.  Clonal selection for transcriptionally active viral oncogenes during progression to cancer.

Authors:  Brian A Van Tine; John C Kappes; N Sanjib Banerjee; Judith Knops; Lilin Lai; Renske D M Steenbergen; Chris L J M Meijer; Peter J F Snijders; Pamela Chatis; Thomas R Broker; Phillip T Moen; Louise T Chow
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

8.  Human papillomavirus type 33 in a tonsillar carcinoma generates its putative E7 mRNA via two E6* transcript species which are terminated at different early region poly(A) sites.

Authors:  P J Snijders; A J van den Brule; H F Schrijnemakers; P M Raaphorst; C J Meijer; J M Walboomers
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

9.  Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas.

Authors:  Bo Xu; Sasithorn Chotewutmontri; Stephan Wolf; Ursula Klos; Martina Schmitz; Matthias Dürst; Elisabeth Schwarz
Journal:  PLoS One       Date:  2013-06-18       Impact factor: 3.240
  9 in total

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