Literature DB >> 18508973

Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants.

Hongyu Ruan1, Chun-Fang Wu.   

Abstract

Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.

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Year:  2008        PMID: 18508973      PMCID: PMC2396722          DOI: 10.1073/pnas.0711127105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  28 in total

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  34 in total

1.  Report on the 12th symposium on invertebrate neurobiology held 31 August-4 September 2011 at the Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary.

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