Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.

Literature DB >> 18508721

FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.

Jinsong Hu¹, Junlin Teng, Naizheng Ding, Mei He, Yuhui Sun, Albert Cheung Hoi Yu, Jianguo Chen.

Abstract

Focal adhesion associated protein (FAAP), encoded by murine D10Wsu52e gene, is highly homologous to human HSPC117, which interacts with vinculin and talin. HeLa cells transfected with FAAP exhibited normal adhesion incorporation but showed impaired cell spreading, and restrained focal adhesion translocation. Moreover, FAAP facilitated vinculin-paxillin association, decreased interaction of paxillin-focal adhesion kinase and inhibited the phosphorylation of extracellular signal-regulated kinase. Together, these results suggest that FAAP, by virtue of modulating interaction of adhesion molecules, regulates cell adhesion dynamics.

Entities: Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18508721 DOI： 10.2741/3215

Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715

Keyword Cloud
Cited

8 in total

1. Expression and regulation of FAAP in the mouse epididymis.

Authors: Nai-Zheng Ding; Mei He; Cheng-Qiang He; Jin-Song Hu; Junlin Teng; Jianguo Chen
Journal: Endocrine Date: 2010-07-11 Impact factor: 3.633

2. Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

Authors: Robert J W Heath; John M Leong; Balázs Visegrády; Laura M Machesky; Ramnik J Xavier
Journal: PLoS Pathog Date: 2011-04-07 Impact factor: 6.823

3. Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformation.

Authors: Jamie G Bates; Julia Salzman; Damon May; Patty B Garcia; Gregory J Hogan; Martin McIntosh; Mark S Schlissel; Pat O Brown
Journal: PLoS One Date: 2012-05-31 Impact factor: 3.240

4. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.

Authors: Xiaoti Lin; Weiyu Chen; Fengqin Wei; Binhua P Zhou; Mien-Chie Hung; Xiaoming Xie
Journal: Theranostics Date: 2017-10-17 Impact factor: 11.556

FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association.

1. Expression and regulation of FAAP in the mouse epididymis.

2. Bacterial and host determinants of MAL activation upon EPEC infection: the roles of Tir, ABRA, and FLRT3.

3. Extensive gene-specific translational reprogramming in a model of B cell differentiation and Abl-dependent transformation.

4. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.

5. Expression and subcellular localization of HSPC117 in min pig tissues and the PK15 cell line.

6. Identification and Functional Characterization of Divergent 3'-Phosphate tRNA Ligase From Entamoeba histolytica.

7. Molecular architecture of the human tRNA ligase complex.

8. HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.