Literature DB >> 18508710

Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosis.

Michael Zeisberg1, Raghu Kalluri.   

Abstract

Our current understanding of epithelial-mesenchymal transition (EMT) in the setting of tissue fibrosis is largely based on pioneering studies in the kidney. Evidence is emerging that EMT is a key component of chronic kidney disease, contributing to both destruction of the tubular epithelial compartment and accumulation of interstitial fibroblasts. While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis.

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Year:  2008        PMID： 18508710     DOI： 10.2741/3204

Source DB:  PubMed          Journal:  Front Biosci        ISSN： 1093-4715


  54 in total

Review 1.  The myofibroblast, a key cell in normal and pathological tissue repair.

Authors:  Ian A Darby; Noraina Zakuan; Fabrice Billet; Alexis Desmoulière
Journal:  Cell Mol Life Sci       Date:  2015-12-17       Impact factor: 9.261

Review 2.  Relationships between eosinophilic inflammation, tissue remodeling, and fibrosis in eosinophilic esophagitis.

Authors:  Seema S Aceves; Steven J Ackerman
Journal:  Immunol Allergy Clin North Am       Date:  2009-02       Impact factor: 3.479

3.  Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.

Authors:  Irina A Leaf; Shunsaku Nakagawa; Bryce G Johnson; Jin Joo Cha; Kristen Mittelsteadt; Kevin M Guckian; Ivan G Gomez; William A Altemeier; Jeremy S Duffield
Journal:  J Clin Invest       Date:  2016-11-21       Impact factor: 14.808

4.  Esophageal epithelial cells acquire functional characteristics of activated myofibroblasts after undergoing an epithelial to mesenchymal transition.

Authors:  Amanda B Muir; Kara Dods; Yuli Noah; Sarit Toltzis; Prasanna Modayur Chandramouleeswaran; Anna Lee; Alain Benitez; Adam Bedenbaugh; Gary W Falk; Rebecca G Wells; Hiroshi Nakagawa; Mei-Lun Wang
Journal:  Exp Cell Res       Date:  2014-08-27       Impact factor: 3.905

Review 5.  Mechanisms of Disease of Eosinophilic Esophagitis.

Authors:  Benjamin P Davis; Marc E Rothenberg
Journal:  Annu Rev Pathol       Date:  2016-02-24       Impact factor: 23.472

6.  The cardiotonic steroid hormone marinobufagenin induces renal fibrosis: implication of epithelial-to-mesenchymal transition.

Authors:  Larisa V Fedorova; Vanamala Raju; Nasser El-Okdi; Amjad Shidyak; David J Kennedy; Sandeep Vetteth; David R Giovannucci; Alexei Y Bagrov; Olga V Fedorova; Joseph I Shapiro; Deepak Malhotra
Journal:  Am J Physiol Renal Physiol       Date:  2009-01-28

Review 7.  Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis.

Authors:  Gabriela Campanholle; Giovanni Ligresti; Sina A Gharib; Jeremy S Duffield
Journal:  Am J Physiol Cell Physiol       Date:  2013-01-16       Impact factor: 4.249

Review 8.  Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis.

Authors:  Michael Zeisberg; Raghu Kalluri
Journal:  Am J Physiol Cell Physiol       Date:  2012-12-19       Impact factor: 4.249

9.  Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis.

Authors:  Boris Hinz
Journal:  Curr Rheumatol Rep       Date:  2009-04       Impact factor: 4.592

10.  JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.

Authors:  Markella Ponticos; Clare Harvey; Tetsuro Ikeda; David Abraham; George Bou-Gharios
Journal:  Nucleic Acids Res       Date:  2009-06-26       Impact factor: 16.971
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