| Literature DB >> 18508502 |
Wilhelmina M Rensen1, Rosamaria Mangiacasale, Marilena Ciciarello, Patrizia Lavia.
Abstract
The GTPase Ran plays a crucial role in nucleo-cytoplasmic transport of tumor suppressors, proto-oncogenes, signaling molecules and transcription factors. It also plays direct roles in mitosis, through which it regulates faithful chromosome segregation and hence the generation of genetically stable cells. Ran operates through a group of effector proteins. In this review we summarize growing evidence suggesting that deregulated activity of Ran or its effectors can contribute to pathways of cell transformation and facilitate tumor progression.Entities:
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Year: 2008 PMID： 18508502 DOI： 10.2741/2996
Source DB: PubMed Journal: Front Biosci ISSN： 1093-4715