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Literature DB >> 18507366

Synthesis and biological evaluation of D-amino acid oxidase inhibitors.

Dana Ferraris¹, Bridget Duvall, Yao-Sen Ko, Ajit G Thomas, Camilo Rojas, Pavel Majer, Kenji Hashimoto, Takashi Tsukamoto.
1. MGI Pharma, Inc.

Abstract

D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids including d-serine, a full agonist at the glycine site of the NMDA receptor. A series of benzo[ d]isoxazol-3-ol derivatives were synthesized and evaluated as DAAO inhibitors. Among them, 5-chloro-benzo[ d]isoxazol-3-ol (CBIO) potently inhibited DAAO with an IC50 in the submicromolar range. Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-serine in rats compared to the oral administration of d-serine alone.

Entities: Chemical Gene Species

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Year: 2008 PMID： 18507366 DOI： 10.1021/jm800200u

Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446

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Cited

36 in total

1. D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

Authors: Jin-Miao Lu; Nian Gong; Yan-Chao Wang; Yong-Xiang Wang
Journal: Br J Pharmacol Date: 2012-03 Impact factor: 8.739

2. Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

Authors: Jesse Alt; Camilo Rojas; Krystyna Wozniak; Ying Wu; Dana Ferraris; Takashi Tsukamoto; Barbara Slusher
Journal: Anal Biochem Date: 2011-08-16 Impact factor: 3.365

3. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[¹¹C]methoxyphenethyl)pyridazin-3(2H)-one, a ¹¹C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.

Authors: Xiaoyun Deng; Yiding Zhang; Zhen Chen; Katsushi Kumata; Richard Van; Jian Rong; Tuo Shao; Akiko Hatori; Wakana Mori; Qingzhen Yu; Kuan Hu; Masayuki Fujinaga; Hsiao-Ying Wey; Yihan Shao; Lee Josephson; Giulia Murtas; Loredano Pollegioni; Ming-Rong Zhang; Steven Liang
Journal: Bioorg Med Chem Lett Date: 2020-06-09 Impact factor: 2.823

4. Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment.

Authors: Laura Caldinelli; Gianluca Molla; Luisa Bracci; Barbara Lelli; Silvia Pileri; Pamela Cappelletti; Silvia Sacchi; Loredano Pollegioni
Journal: Protein Sci Date: 2010-08 Impact factor: 6.725

Synthesis and biological evaluation of D-amino acid oxidase inhibitors.

1. D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.

2. Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

3. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[¹¹C]methoxyphenethyl)pyridazin-3(2H)-one, a ¹¹C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging.

4. Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment.

5. D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.

Review 6. Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders.

7. Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

8. Novel therapeutic drugs for neuropsychiatric disorders.

9. The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

Review 10. The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.