AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells. METHODS: Eight patients with CRCLM underwent CE-IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid. RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for 10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis. CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.
AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells. METHODS: Eight patients with CRCLM underwent CE-IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid. RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for 10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis. CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.
Authors: Daniel Jaeck; Philippe Bachellier; Hiroshi Nakano; Elie Oussoultzoglou; Jean-Christophe Weber; Philippe Wolf; Michel Greget Journal: Am J Surg Date: 2003-03 Impact factor: 2.565
Authors: Y Fong; A M Cohen; J G Fortner; W E Enker; A D Turnbull; D G Coit; A M Marrero; M Prasad; L H Blumgart; M F Brennan Journal: J Clin Oncol Date: 1997-03 Impact factor: 44.544
Authors: E K Hagen; F Forsberg; A K Aksnes; D A Merton; J B Liu; A Tornes; D Johnson; B B Goldberg Journal: Invest Radiol Date: 2000-02 Impact factor: 6.016
Authors: Flemming Forsberg; Catherine W Piccoli; Ji-Bin Liu; Nandkumar M Rawool; Daniel A Merton; Donald G Mitchell; Barry B Goldberg Journal: Radiology Date: 2002-03 Impact factor: 11.105
Authors: J C Weber; H Nakano; P Bachellier; E Oussoultzoglou; K Inoue; H Shimura; P Wolf; M P Chenard-Neu; D Jaeck Journal: Am J Surg Date: 2001-07 Impact factor: 2.565
Authors: W R Jarnagin; A M Bach; C B Winston; L E Hann; N Heffernan; T Loumeau; R P DeMatteo; Y Fong; L H Blumgart Journal: J Am Coll Surg Date: 2001-05 Impact factor: 6.113
Authors: Yuko Kono; Gregory C Steinbach; Thomas Peterson; Geert W Schmid-Schönbein; Robert F Mattrey Journal: Radiology Date: 2002-07 Impact factor: 11.105