| Literature DB >> 185067 |
W H Gispen, J Buitelaar, V M Wiegant, L Terenius, D De Wied.
Abstract
The present study confirms that N-terminal fragments of ACTH have an affinity for rat brain opiate receptors in vitro. Such peptides, devoid of corticotrophic activity, were found to inhibit morphine-induced analgesia if they also possessed affinity for opiate receptors in vitro. The structure-activity relationship for these two parameters is comparable to that observed for the same peptides on the induction of excessive grooming.Entities:
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Year: 1976 PMID： 185067 DOI： 10.1016/0014-2999(76)90150-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432