UNLABELLED: The aim of the study was to evaluate the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in breast, lung and colorectal cancer patients in correlation with clinical variables. PATIENTS AND METHODS: A total of 59 patients with a median age of 64 years and histologically confirmed breast 14, colorectal 15 or lung cancer 30 were evaluated. Five patients with breast cancer, 7 patients with colorectal cancer and 8 patients with lung cancer had lung metastases. Blood was collected upon enrolment, centrifuged and the serum kept at -80 degrees C until assayed for sTREM-1. The estimation of sTREM-1 was performed by a crude enzyme immunoabsorbent assay. RESULTS: High levels of sTREM-1 were observed in 50% of breast cancer, 33.3% of Small Cell Lung carcinoma (SCLC), 26.7% of colorectal cancer and 13.3% of Non Small Cell Lung Carcinoma (NSCLC) patients. sTREM-1 expression showed a correlation to the site of metastases. Higher concentrations were observed in the absence of lung metastases (p=0.019). DISCUSSION: The novel mediator sTREM-1 may be a prognostic marker for the detection of lung metastases in metastatic and locally advanced solid tumors.
UNLABELLED: The aim of the study was to evaluate the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in breast, lung and colorectal cancerpatients in correlation with clinical variables. PATIENTS AND METHODS: A total of 59 patients with a median age of 64 years and histologically confirmed breast 14, colorectal 15 or lung cancer 30 were evaluated. Five patients with breast cancer, 7 patients with colorectal cancer and 8 patients with lung cancer had lung metastases. Blood was collected upon enrolment, centrifuged and the serum kept at -80 degrees C until assayed for sTREM-1. The estimation of sTREM-1 was performed by a crude enzyme immunoabsorbent assay. RESULTS: High levels of sTREM-1 were observed in 50% of breast cancer, 33.3% of Small Cell Lung carcinoma (SCLC), 26.7% of colorectal cancer and 13.3% of Non Small Cell Lung Carcinoma (NSCLC) patients. sTREM-1 expression showed a correlation to the site of metastases. Higher concentrations were observed in the absence of lung metastases (p=0.019). DISCUSSION: The novel mediator sTREM-1 may be a prognostic marker for the detection of lung metastases in metastatic and locally advanced solid tumors.
Authors: K Kluckova; J Kozak; K Szaboova; B Rychly; M Svajdler; M Suchankova; E Tibenska; B Filova; J Steno; V Matejcik; M Homolova; M Bucova Journal: Mediators Inflamm Date: 2020-07-01 Impact factor: 4.711
Authors: Marie Muller; Vincent Haghnejad; Anthony Lopez; Angelica Tiotiu; Stéphane Renaud; Marc Derive; Jean-Pierre Bronowicki Journal: Front Oncol Date: 2022-07-08 Impact factor: 5.738
Authors: Andreas Kuemmel; Astrid Alflen; Lars Henning Schmidt; Martin Sebastian; Rainer Wiewrodt; Arik Bernard Schulze; Roland Buhl; Markus Radsak Journal: Sci Rep Date: 2018-07-17 Impact factor: 4.379