BACKGROUND: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. PATIENTS AND METHODS: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. RESULTS: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. CONCLUSION: A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here.
BACKGROUND: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. PATIENTS AND METHODS: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. RESULTS: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. CONCLUSION: A randomized controlled study should be conducted in advanced gastric cancerpatients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here.
Authors: Amy Collins; Ioannis Hatzaras; Carl Schmidt; Katherine Carruthers; W Scott Melvin; Pete Muscarella; E Christopher Ellison; Edward Martin; Mark Bloomston Journal: J Gastrointest Surg Date: 2014-03 Impact factor: 3.452
Authors: Mushegh А Sahakyan; Artak Gabrielyan; Davit L Aghayan; Shushan Yesayan; Hmayak Petrosyan; Аlina Chobanyan; Airazat M Kazaryan; Artur M Sahakyan Journal: Indian J Surg Oncol Date: 2019-05-29
Authors: Elisa Gálvez-Muñoz; Javier Gallego-Plazas; Verónica Gonzalez-Orozco; Francisco Menarguez-Pina; José A Ruiz-Maciá; Miguel A Morcillo Journal: Int Semin Surg Oncol Date: 2009-08-12