Literature DB >> 18504508

The Pathobiology of Krüppel-like Factors in Colorectal Cancer.

Amr M Ghaleb, Vincent W Yang.   

Abstract

The Krüppel-like factor (KLF) proteins are zinc finger-containing transcription factors that exert important functions in regulating diverse biologic processes such as growth, proliferation, differentiation, development, inflammation, and apoptosis. Many KLFs have also been shown to play significant roles in tumorigenesis of various organs and tissues. Three in particular-KLF4, KLF5, and KLF6-are often dysregulated in tumors of the gastrointestinal tract, including colorectal cancer. This article reviews the functions of these three KLFs in normal gastrointestinal biology and their pathobiologic roles in colorectal cancer.

Entities:  

Year:  2008        PMID： 18504508      PMCID： PMC2394726          DOI： 10.1007/s11888-008-0011-4

Source DB:  PubMed          Journal:  Curr Colorectal Cancer Rep        ISSN： 1556-3790


  67 in total

1.  cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.

Authors:  K Sogawa; H Imataka; Y Yamasaki; H Kusume; H Abe; Y Fujii-Kuriyama
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

2.  Genetic alterations of the KLF6 gene in gastric cancer.

Authors:  Yong Gu Cho; Chang Jae Kim; Cho Hyun Park; Young Mok Yang; Su Young Kim; Suk Woo Nam; Sug Hyung Lee; Nam Jin Yoo; Jung Young Lee; Won Sang Park
Journal:  Oncogene       Date:  2005-06-30       Impact factor: 9.867

3.  Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest.

Authors:  J M Shields; R J Christy; V W Yang
Journal:  J Biol Chem       Date:  1996-08-16       Impact factor: 5.157

4.  Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation.

Authors:  J L Shie; Z Y Chen; M J O'Brien; R G Pestell; M E Lee; C C Tseng
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-10       Impact factor: 4.052

5.  Molecular Genetics of Colorectal Cancer: An Overview.

Authors:  Irfan M Hisamuddin; Vincent W Yang
Journal:  Curr Colorectal Cancer Rep       Date:  2006-04

6.  Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.

Authors:  Mandayam O Nandan; Sengthong Chanchevalap; W Brian Dalton; Vincent W Yang
Journal:  FEBS Lett       Date:  2005-08-29       Impact factor: 4.124

7.  A gene encoding an intestinal-enriched member of the Krüppel-like factor family expressed in intestinal epithelial cells.

Authors:  M D Conkright; M A Wani; K P Anderson; J B Lingrel
Journal:  Nucleic Acids Res       Date:  1999-03-01       Impact factor: 16.971

8.  Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.

Authors:  Takayuki Shindo; Ichiro Manabe; Yasushi Fukushima; Kazuyuki Tobe; Kenichi Aizawa; Saku Miyamoto; Keiko Kawai-Kowase; Nobuo Moriyama; Yasushi Imai; Hayato Kawakami; Hiroaki Nishimatsu; Takashi Ishikawa; Toru Suzuki; Hiroyuki Morita; Koji Maemura; Masataka Sata; Yasunobu Hirata; Masayuki Komukai; Hiroyuki Kagechika; Takashi Kadowaki; Masahiko Kurabayashi; Ryozo Nagai
Journal:  Nat Med       Date:  2002-07-08       Impact factor: 53.440

9.  Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

Authors:  Sharon Benzeno; Goutham Narla; Jorge Allina; George Z Cheng; Helen L Reeves; Michaela S Banck; Joseph A Odin; J Alan Diehl; Doris Germain; Scott L Friedman
Journal:  Cancer Res       Date:  2004-06-01       Impact factor: 12.701

10.  KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells.

Authors:  Volker Ellenrieder; Anita Buck; Ana Harth; Kerstin Jungert; Malte Buchholz; Guido Adler; Raul Urrutia; Thomas M Gress
Journal:  Gastroenterology       Date:  2004-08       Impact factor: 22.682
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  28 in total

1.  Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling.

Authors:  Rajendran Sellamuthu; Christina Umbright; Shengqiao Li; Michael Kashon; Pius Joseph
Journal:  Inhal Toxicol       Date:  2011-11-16       Impact factor: 2.724

2.  Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome.

Authors:  Changyu Zhou; Jiayu Li; Jiarui Li; Yingchun Wan; Tao Li; Piyong Ma; Yingjian Wang; Haiyan Sang
Journal:  Oncol Lett       Date:  2016-07-06       Impact factor: 2.967

3.  A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.

Authors:  James X Du; Beth B McConnell; Vincent W Yang
Journal:  J Biol Chem       Date:  2010-06-28       Impact factor: 5.157

4.  Proteasome inhibitors enhance endothelial thrombomodulin expression via induction of Krüppel-like transcription factors.

Authors:  Toyoko Hiroi; Clayton B Deming; Haige Zhao; Baranda S Hansen; Elisabeth K Arkenbout; Thomas J Myers; Michael A McDevitt; Jeffrey J Rade
Journal:  Arterioscler Thromb Vasc Biol       Date:  2009-08-06       Impact factor: 8.311

5.  Retinoic acid receptor α mediates all-trans-retinoic acid-induced Klf4 gene expression by regulating Klf4 promoter activity in vascular smooth muscle cells.

Authors:  Jian-hong Shi; Bin Zheng; Si Chen; Guo-yan Ma; Jin-kun Wen
Journal:  J Biol Chem       Date:  2012-02-15       Impact factor: 5.157

6.  KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.

Authors:  T Yu; X Chen; W Zhang; J Liu; R Avdiushko; D L Napier; A X Liu; J M Neltner; C Wang; D Cohen; C Liu
Journal:  Cell Death Differ       Date:  2015-06-26       Impact factor: 15.828

7.  Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt.

Authors:  Jes G Kuruvilla; Amr M Ghaleb; Agnieszka B Bialkowska; Mandayam O Nandan; Vincent W Yang
Journal:  Stem Cell Transl Investig       Date:  2015

8.  The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Authors:  Joongho Shin; Azadeh Carr; Georgia A Corner; Lars Tögel; Mercedes Dávalos-Salas; Mercedes Dávaos-Salas; Hoanh Tran; Anderly C Chueh; Sheren Al-Obaidi; Fiona Chionh; Naseem Ahmed; Daniel D Buchanan; Joanne P Young; Madhu S Malo; Richard A Hodin; Diego Arango; Oliver M Sieber; Leonard H Augenlicht; Amardeep S Dhillon; Thomas K Weber; John M Mariadason
Journal:  J Biol Chem       Date:  2014-07-18       Impact factor: 5.157

9.  Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable.

Authors:  E G Hagos; A M Ghaleb; W B Dalton; A B Bialkowska; V W Yang
Journal:  Oncogene       Date:  2009-01-12       Impact factor: 9.867

10.  Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.

Authors:  Agnieszka B Bialkowska; Yuhong Du; Haian Fu; Vincent W Yang
Journal:  Mol Cancer Ther       Date:  2009-02-24       Impact factor: 6.261
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