| Literature DB >> 18503205 |
Aiqun Lin1, Xiaoming Lu, Yuchun Fang, Tianjiao Zhu, Qianqun Gu, Weiming Zhu.
Abstract
Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells in a dose-dependent manner, which indicated 1 might be a possible ligand for GPR12.Entities:
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Year: 2008 PMID： 18503205 DOI： 10.1038/ja.2008.36
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649