| Literature DB >> 18501638 |
R Sanchez-Pernaute1, J-Q Wang, D Kuruppu, L Cao, W Tueckmantel, A Kozikowski, O Isacson, A-L Brownell.
Abstract
The interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. Metabotropic glutamate receptors (mGluR) are increasingly regarded as key modulators of neuroadaptation in these circuits, in normal and disease conditions. Using PET, we demonstrate a significant upregulation of mGluR type 5 in the striatum of MPTP-lesioned, parkinsonian primates, providing the basis for therapeutic exploration of mGluR5 antagonists in Parkinson disease.Entities:
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Year: 2008 PMID： 18501638 PMCID： PMC2532975 DOI： 10.1016/j.neuroimage.2008.04.170
Source DB: PubMed Journal: Neuroimage ISSN： 1053-8119 Impact factor: 6.556