Literature DB >> 18501602

Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.

Alistair H Bingham1, Richard J Davenport, Richard Fosbeary, Lewis Gowers, Roland L Knight, Christopher Lowe, David A Owen, David M Parry, Will R Pitt.   

Abstract

The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.

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Year:  2008        PMID: 18501602     DOI: 10.1016/j.bmcl.2008.04.062

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  Discovery of a novel IKK-β inhibitor by ligand-based virtual screening techniques.

Authors:  Stefan M Noha; Atanas G Atanasov; Daniela Schuster; Patrick Markt; Nanang Fakhrudin; Elke H Heiss; Olivia Schrammel; Judith M Rollinger; Hermann Stuppner; Verena M Dirsch; Gerhard Wolber
Journal:  Bioorg Med Chem Lett       Date:  2010-10-20       Impact factor: 2.823

2.  Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays.

Authors:  Esther Sala; Laura Guasch; Justyna Iwaszkiewicz; Miquel Mulero; Maria-Josepa Salvadó; Montserrat Pinent; Vincent Zoete; Aurélien Grosdidier; Santiago Garcia-Vallvé; Olivier Michielin; Gerard Pujadas
Journal:  PLoS One       Date:  2011-02-24       Impact factor: 3.240

3.  Synthesis and Spectroscopic Analysis of Novel 1H-Benzo[d]imidazoles Phenyl Sulfonylpiperazines.

Authors:  Amjad M Qandil
Journal:  Pharmaceuticals (Basel)       Date:  2012-05-03
  3 in total

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