| Literature DB >> 18501554 |
Masato Tachibana1, Kenta Watanabe, Yuki Yamasaki, Hiroshi Suzuki, Masahisa Watarai.
Abstract
Brucella abortus is a facultative intracellular pathogen that can survive inside macrophages and trophoblast giant (TG) cells, and the causative agent of brucellosis. In the present study, we found that expression of heme oxygenase-1 (HO-1) in TG cells is correlated with abortion induced by B. abortus infection in pregnant mice. Expression of HO-1 in the placenta was decreased by B. abortus infection and treatment with cobalt-protoporphyrin (Co-PP), which is known to up-regulate HO-1 expression, inhibited abortion due to the bacterial infection. In TG cells, treatment with Co-PP was shown to up-regulate HO-1, whereas its expression was decreased by B. abortus infection. Such down-regulation of HO-1 in the TG cells was enhanced by IFN-gamma treatment. HO-1 down-regulation in TG cells due to knockdown or IFN-gamma treatment served to induce cell death caused by B. abortus infection. These results suggest that down-regulation of HO-1 in TG cells due to B. abortus infection is an important event in infectious abortion.Entities:
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Year: 2008 PMID： 18501554 DOI： 10.1016/j.micpath.2008.04.002
Source DB: PubMed Journal: Microb Pathog ISSN： 0882-4010 Impact factor: 3.738