P Merviel1, L Touzart, V Deslandes, M Delmas, M Coicaud, J Gondry. 1. Service de gynécologie-obstétrique et médecine de la reproduction, CHU d'Amiens, 124, rue Camille-Desmoulins, 80054 Amiens cedex 1, France. Merviel.Philippe@chu-amiens.fr
Abstract
OBJECTIVES: Study of the clinical risk factors of preeclampsia during a single pregnancy. MATERIALS AND METHODS: Retrospective case-control study during five years. RESULTS: One hundred and eighty-eight cases of preeclampsia have been studied, with 147 called severe (78.2%). We find as risk factors: first pregnancy (OR=2.11; IC 95% [1.30-3.35]), primiparity (OR=2.67; IC 95% [1.67-4.29]), primipaternity (OR=3.55; IC 95% [2.13-5.83], maternal overweight (OR=2.50; IC 95% [1.55-4.05]), personal history of preeclampsia (OR=8.12; IC 95% [2.37-45.65]), personal history of hypertension (OR=2.77; IC 95% [1.01-7.99]), familial history of preeclampsia (OR=1.04; IC 95% [1.01-1.08]), familial history of hypertension at the first step (OR=2.61; IC 95% [1.32-5.47]). Two elements have been found as protected: tobacco before pregnancy (OR=0.51; IC 95% [0.36-0.85]), tobacco during pregnancy (OR=0.52; IC 95% [0.30-0.92]). CONCLUSION: Preeclampsia is responsible of a high maternal and fetal morbidity. The risk factors are widespread, the only use of them is not enough to determine the individual risk. A second step could be to determine if biological markers are better than clinical factors.
OBJECTIVES: Study of the clinical risk factors of preeclampsia during a single pregnancy. MATERIALS AND METHODS: Retrospective case-control study during five years. RESULTS: One hundred and eighty-eight cases of preeclampsia have been studied, with 147 called severe (78.2%). We find as risk factors: first pregnancy (OR=2.11; IC 95% [1.30-3.35]), primiparity (OR=2.67; IC 95% [1.67-4.29]), primipaternity (OR=3.55; IC 95% [2.13-5.83], maternal overweight (OR=2.50; IC 95% [1.55-4.05]), personal history of preeclampsia (OR=8.12; IC 95% [2.37-45.65]), personal history of hypertension (OR=2.77; IC 95% [1.01-7.99]), familial history of preeclampsia (OR=1.04; IC 95% [1.01-1.08]), familial history of hypertension at the first step (OR=2.61; IC 95% [1.32-5.47]). Two elements have been found as protected: tobacco before pregnancy (OR=0.51; IC 95% [0.36-0.85]), tobacco during pregnancy (OR=0.52; IC 95% [0.30-0.92]). CONCLUSION: Preeclampsia is responsible of a high maternal and fetal morbidity. The risk factors are widespread, the only use of them is not enough to determine the individual risk. A second step could be to determine if biological markers are better than clinical factors.
Authors: Deborah van Middendorp; Augustinus ten Asbroek; Fred Yaw Bio; Anthony Edusei; Lyonne Meijjer; Sam Newton; Charles Agyemang Journal: Global Health Date: 2013-11-14 Impact factor: 4.185