Literature DB >> 18500642

Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease.

J N Crawley1.   

Abstract

The neuropeptide galanin and its receptors are localized in brain pathways mediating learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galanin display deficits in some learning and memory tests. The inhibitory role of galanin in cognitive processes, taken together with the overexpression of galanin in Alzheimer's disease, suggests that galanin antagonists may offer a novel therapeutic approach to treat memory loss in Alzheimer's patients.

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Year:  2008        PMID： 18500642      PMCID： PMC2711438          DOI： 10.1007/s00018-008-8158-3

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  77 in total

1.  Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease.

Authors:  R A Steiner; J G Hohmann; A Holmes; C C Wrenn; G Cadd; A Juréus; D K Clifton; M Luo; M Gutshall; S Y Ma; E J Mufson; J N Crawley
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-20       Impact factor: 11.205

Review 2.  Pharmacological evidence supporting a role for galanin in cognition and affect.

Authors:  C C Wrenn; J N Crawley
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2001-01       Impact factor: 5.067

3.  Modulation of hippocampal excitability and seizures by galanin.

Authors:  A M Mazarati; J G Hohmann; A Bacon; H Liu; R Sankar; R A Steiner; D Wynick; C G Wasterlain
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

4.  Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin.

Authors:  M Kokaia; K Holmberg; A Nanobashvili; Z Q Xu; Z Kokaia; U Lendahl; S Hilke; E Theodorsson; U Kahl; T Bartfai; O Lindvall; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  2001-11-06       Impact factor: 11.205

5.  Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein--initial observations.

Authors:  M Diez; J Koistinaho; K Kahn; D Games; T Hökfelt
Journal:  Neuroscience       Date:  2000       Impact factor: 3.590

6.  Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons.

Authors:  G O'Meara; U Coumis; S Y Ma; J Kehr; S Mahoney; A Bacon; S J Allen; F Holmes; U Kahl; F H Wang; I R Kearns; S Ove-Ogren; D Dawbarn; E J Mufson; C Davies; G Dawson; D Wynick
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

7.  Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice.

Authors:  Andrew Holmes; Rebecca J Yang; Jacqueline N Crawley
Journal:  J Mol Neurosci       Date:  2002 Feb-Apr       Impact factor: 3.444

Review 8.  Galanin: an endogenous anticonvulsant?

Authors:  A Mazarati; U Langel; T Bartfai
Journal:  Neuroscientist       Date:  2001-12       Impact factor: 7.519

Review 9.  Galanin: neurobiologic mechanisms and therapeutic potential for Alzheimer's disease.

Authors:  S E Counts; S E Perez; U Kahl; T Bartfai; R P Bowser; D C Deecher; D C Mash; J N Crawley; E J Mufson
Journal:  CNS Drug Rev       Date:  2001

10.  Deficits in trace cued fear conditioning in galanin-treated rats and galanin-overexpressing transgenic mice.

Authors:  Jefferson W Kinney; Grzegorz Starosta; Andrew Holmes; Craige C Wrenn; Rebecca J Yang; Ashley P Harris; Katharine C Long; Jacqueline N Crawley
Journal:  Learn Mem       Date:  2002 Jul-Aug       Impact factor: 2.460
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  18 in total

1.  C4ORF48, a gene from the Wolf-Hirschhorn syndrome critical region, encodes a putative neuropeptide and is expressed during neocortex and cerebellar development.

Authors:  Sabine Endele; Claudia Nelkenbrecher; Annegret Bördlein; Stefanie Schlickum; Andreas Winterpacht
Journal:  Neurogenetics       Date:  2011-02-02       Impact factor: 2.660

Review 2.  Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.

Authors:  Elliott J Mufson; Scott E Counts; Sylvia E Perez; Stephen D Ginsberg
Journal:  Expert Rev Neurother       Date:  2008-11       Impact factor: 4.618

3.  Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2.

Authors:  Vasudeva Naidu Sagi; Tianyu Liu; Xiaoying Lu; Tamas Bartfai; Edward Roberts
Journal:  Bioorg Med Chem Lett       Date:  2011-09-25       Impact factor: 2.823

4.  Pharmacogenetic association of the galanin receptor (GALR1) SNP rs2717162 with smoking cessation.

Authors:  Allison B Gold; E Paul Wileyto; Adriana Lori; David Conti; Joseph F Cubells; Caryn Lerman
Journal:  Neuropsychopharmacology       Date:  2012-02-29       Impact factor: 7.853

5.  Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.

Authors:  Joanne C Damborsky; Kathleen G Smith; Patricia Jensen; Jerrel L Yakel
Journal:  Brain Struct Funct       Date:  2016-08-05       Impact factor: 3.270

6.  Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms.

Authors:  Marine Jequier Gygax; Brian D Klein; H Steve White; Mimi Kim; Aristea S Galanopoulou
Journal:  Epilepsy Res       Date:  2013-10-28       Impact factor: 3.045

7.  Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055.

Authors:  Sean P Flynn; H Steve White
Journal:  Neuropeptides       Date:  2015-01-21       Impact factor: 3.286

8.  Bidirectional regulation of stress responses by galanin in mice: involvement of galanin receptor subtype 1.

Authors:  K Mitsukawa; X Lu; T Bartfai
Journal:  Neuroscience       Date:  2009-03-09       Impact factor: 3.590

Review 9.  Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors.

Authors:  Marina R Picciotto; Christian Brabant; Emily B Einstein; Helen M Kamens; Nichole M Neugebauer
Journal:  Brain Res       Date:  2009-08-20       Impact factor: 3.252

Review 10.  Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.

Authors:  David Weinshenker; Philip V Holmes
Journal:  Brain Res       Date:  2015-11-20       Impact factor: 3.252
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