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Literature DB >> 18500393

The role and the mechanism of gamma-aminobutyric acid during central nervous system development.

Abstract

gamma -aminobutyric acid (GABA) is an inhibitory neurotransmitter in adult mammalian central nervous system (CNS). During CNS development, the role of GABA is switched from an excitatory transmitter to an inhibitory transmitter, which is caused by an inhibition of calcium influx into postsynaptic neuron derived from release of GABA. The switch is influenced by the neuronal chloride concentration. When the neuronal chloride concentration is at a high level, GABA acts as an excitatory neurotransmitter. When neuronal chloride concentration decreases to some degree, GABA acts as an inhibitory neurotransmitter. The neuronal chloride concentration is increased by Na+-K+-Cl(-)-Cl(-) cotransporters 1 (NKCC1), and decreased by K+-Cl(-) cotransporter 2 (KCC2).

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Year: 2008 PMID： 18500393 PMCID： PMC5552538 DOI： 10.1007/s12264-008-0109-3

Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203

23 in total

Review 1. Sodium-potassium-chloride cotransport.

Authors: J M Russell
Journal: Physiol Rev Date: 2000-01 Impact factor: 37.312

2. Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice.

Authors: K W Sung; M Kirby; M P McDonald; D M Lovinger; E Delpire
Journal: J Neurosci Date: 2000-10-15 Impact factor: 6.167

3. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

Authors: Kristopher T Kahle; Jesse Rinehart; Paola de Los Heros; Angeliki Louvi; Patricia Meade; Norma Vazquez; Steven C Hebert; Gerardo Gamba; Ignacio Gimenez; Richard P Lifton
Journal: Proc Natl Acad Sci U S A Date: 2005-11-07 Impact factor: 11.205

4. A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.

Authors: Adriana Mercado; Vadjista Broumand; Kambiz Zandi-Nejad; Alissa H Enck; David B Mount
Journal: J Biol Chem Date: 2005-11-16 Impact factor: 5.157

Review 5. Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters.

Authors: Ignacio Giménez
Journal: Curr Opin Nephrol Hypertens Date: 2006-09 Impact factor: 2.894

6. Diversity of neuron-specific K+-Cl- cotransporter expression and inhibitory postsynaptic potential depression in rat motoneurons.

Authors: Tsuyoshi Ueno; Akihito Okabe; Norio Akaike; Atsuo Fukuda; Junichi Nabekura
Journal: J Biol Chem Date: 2001-12-03 Impact factor: 5.157

7. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain.

Authors: D L Martin; S B Martin; S J Wu; N Espina
Journal: J Neurosci Date: 1991-09 Impact factor: 6.167

8. Intracellular calcium increase induced by GABA in visual cortex of fetal and neonatal rats and its disappearance with development.

Authors: M H Lin; M P Takahashi; Y Takahashi; T Tsumoto
Journal: Neurosci Res Date: 1994-07 Impact factor: 3.304

9. Urotensin II inhibits electrical activity of hippoCampal CA1 neurons by potentiating the GABA(A) receptor-mediated Cl(-) current.

Authors: Yu-Ming Wu; Ru Wang; Rui-Rong He
Journal: Neurosci Bull Date: 2006-03 Impact factor: 5.203

The role and the mechanism of gamma-aminobutyric acid during central nervous system development.

Review 1. Sodium-potassium-chloride cotransport.

2. Abnormal GABAA receptor-mediated currents in dorsal root ganglion neurons isolated from Na-K-2Cl cotransporter null mice.

3. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability.

4. A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.

Review 5. Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters.

6. Diversity of neuron-specific K+-Cl- cotransporter expression and inhibitory postsynaptic potential depression in rat motoneurons.

7. Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain.

8. Intracellular calcium increase induced by GABA in visual cortex of fetal and neonatal rats and its disappearance with development.

9. Urotensin II inhibits electrical activity of hippoCampal CA1 neurons by potentiating the GABA(A) receptor-mediated Cl(-) current.

10. Elevated [Cl-]i, and [Na+]i inhibit Na+, K+, Cl- cotransport by different mechanisms in squid giant axons.

1. Downregulation of hippocampal GABA after hypoxia-induced seizures in neonatal rats.

2. The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice.

3. Micellar electrokinetic chromatography method for measuring amino acid secretions from islets of Langerhans.

4. Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome.

5. Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder.

6. Neurocognitive Functioning in Depressed Young People: A Systematic Review and Meta-Analysis.

7. GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans.

8. A photoprotein in mouse embryonic stem cells measures Ca2+ mobilization in cells and in animals.

9. Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medulla.

10. Functional analysis of calcium channel-mediated exocytosis in synaptic terminals by FM imaging technique.