Literature DB >> 18500183

Ecchymosis-like hyperpigmented mycosis fungoides.

Mohammad R Namazi1.   

Abstract

Entities:  

Mesh:

Year:  2008        PMID: 18500183      PMCID: PMC6074424          DOI: 10.5144/0256-4947.2008.228

Source DB:  PubMed          Journal:  Ann Saudi Med        ISSN: 0256-4947            Impact factor:   1.526


× No keyword cloud information.
A 52-year-old lady presented with a 10-year history of a widespread, gradually expanding, bruise-like, pruritic macular eruption. She was not on medications and had normal lab data. including platelet count and coagulation profiles. The patient stated that her condition was diagnosed by an experienced dermatologist as senile bruises and xerosis. She was prescribed a bland emollient plus an antihistamine. Histologic examination of a representative lesion demonstrated hyperkeratosis, acanthosis, severe pigment incontinence, and dense band-like infiltration in the papillary dermis composed mainly of lymphocytes with the majority having enlarged hyperchromatic indented nuclei. Epidermotropism of highly atypical lymphocytes with formation of Pautrier’s microabscesses was also noted. On immunohistochemical staining, nearly all the intraepidermal and dermal lymphocytes were positive for CD3 and negative for CD20, with less than 5% being positive for CD5 and CD7. The patient’s condition was diagnosed as mycosis fungoides. Mycosis fungoides, the most common variant of cutaneous T cell lymphoma, is characterized by subtle fine scaly and often slightly atrophic erythematous patches on the trunk. There are a large number of clinical variants. Some plaques have a rather verrucous or hyperkeratotic appearance,1 and bullae may rarely develop in the course of the progression of the plaques.2 Rare ichthyosiform variants and a pilotropic (folliculotropic) variant giving rise to a follicular clinical pattern often with alopecia have also been described.3 Presentation with lesions not unlike pigmented purpuric dermatosis is reported in younger patients.3,4 Non-white younger adult patients may also present with a hypopigmented variant of mycosis fungoides5 characterized by striking hypopigmented scaly patches often involving the trunk and especially the pelvic girdle area rather than the limbs. In poikilodermatous mycosis fungoides, patients present with clinical lesions characterized by either widespread or isolated poikiloderma, which may or may not be associated with typical lesions of mycosis fungoides. This variant must be distinguished from poikiloderma resulting from other disorders by appropriate histology. Rarely, patients may have extensive poikiloderma as a feature of erythrodermic disease.6
  4 in total

1.  Mycosis fungoides presenting as pigmented purpuric dermatitis.

Authors:  Shannon Hanna; Noreen Walsh; Yolanda D'Intino; Richard G B Langley
Journal:  Pediatr Dermatol       Date:  2006 Jul-Aug       Impact factor: 1.588

2.  Mycosis fungoides bullosa.

Authors:  H H Roenigk; A J Castrovinci
Journal:  Arch Dermatol       Date:  1971-10

3.  Hyperkeratotic and verrucous features of mycosis fungoides.

Authors:  N M Price; Z Y Fuks; T E Hoffman
Journal:  Arch Dermatol       Date:  1977-01

4.  Mycosis fungoides presenting with areas of cutaneous hypopigmentation.

Authors:  N P Smith; P D Samman
Journal:  Clin Exp Dermatol       Date:  1978-06       Impact factor: 3.470

  4 in total
  2 in total

1.  Serpiginous mycosis fungoides in a 21-year-old man.

Authors:  Judy K Qiang; Joseph E Marinas; Dusan Sajic; Jensen Yeung
Journal:  JAAD Case Rep       Date:  2015-03-11

2.  Hyperpigmentation as a peculiar presentation of mycosis fungoides.

Authors:  Ying-Yi Lu; Chieh-Hsin Wu; Chun-Ching Lu; Chien-Hui Hong
Journal:  An Bras Dermatol       Date:  2017       Impact factor: 1.896

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.