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Literature DB >> 18499722

Unresolved issues and controversies in purinergic signalling.

Abstract

Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18499722 PMCID： PMC2538804 DOI： 10.1113/jphysiol.2008.155903

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

51 in total

Review 1. P2 receptor web: complexity and fine-tuning.

Authors: Cinzia Volonté; Susanna Amadio; Nadia D'Ambrosi; Monica Colpi; Geoffrey Burnstock
Journal: Pharmacol Ther Date: 2006-06-15 Impact factor: 12.310

Review 2. Physiology and pathophysiology of purinergic neurotransmission.

Authors: Geoffrey Burnstock
Journal: Physiol Rev Date: 2007-04 Impact factor: 37.312

3. UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.

Authors: Schuichi Koizumi; Yukari Shigemoto-Mogami; Kaoru Nasu-Tada; Yoichi Shinozaki; Keiko Ohsawa; Makoto Tsuda; Bhalchandra V Joshi; Kenneth A Jacobson; Shinichi Kohsaka; Kazuhide Inoue
Journal: Nature Date: 2007-04-04 Impact factor: 49.962

4. ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol 3-kinase/Akt, and mitogen-activated protein kinase signaling pathways.

Authors: Jung Sun Heo; Ho Jae Han
Journal: Stem Cells Date: 2006-08-17 Impact factor: 6.277

Review 5. Purine and pyrimidine receptors.

Authors: G Burnstock
Journal: Cell Mol Life Sci Date: 2007-06 Impact factor: 9.261

6. Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex.

Authors: Silviu Locovei; Eliana Scemes; Feng Qiu; David C Spray; Gerhard Dahl
Journal: FEBS Lett Date: 2007-01-16 Impact factor: 4.124

Review 7. P2X receptors as cell-surface ATP sensors in health and disease.

Authors: Baljit S Khakh; R Alan North
Journal: Nature Date: 2006-08-03 Impact factor: 49.962

8. A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages.

Authors: Anne N Shemon; Ronald Sluyter; Suran L Fernando; Alison L Clarke; Lan-Phuong Dao-Ung; Kristen K Skarratt; Bernadette M Saunders; Khai See Tan; Ben J Gu; Stephen J Fuller; Warwick J Britton; Steven Petrou; James S Wiley
Journal: J Biol Chem Date: 2005-11-01 Impact factor: 5.157

9. Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway.

Authors: Pablo Pelegrin; Annmarie Surprenant
Journal: J Biol Chem Date: 2006-11-22 Impact factor: 5.157

Review 10. Regulation of immune response by P2X7 receptor.

Authors: Lanfen Chen; Celia F Brosnan
Journal: Crit Rev Immunol Date: 2006 Impact factor: 2.214

23 in total

Review 1. The touching story of purinergic signaling in epithelial and endothelial cells.

Authors: Jenny Öhman; David Erlinge
Journal: Purinergic Signal Date: 2012-04-24 Impact factor: 3.765

Review 2. Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors: Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal: Purinergic Signal Date: 2012-05-01 Impact factor: 3.765

3. Ectodermal P2X receptor function plays a pivotal role in craniofacial development of the zebrafish.

Authors: Sarah Kucenas; Jane A Cox; Florentina Soto; Angela Lamora; Mark M Voigt
Journal: Purinergic Signal Date: 2009-06-16 Impact factor: 3.765

4. Imaging exocytosis of ATP-containing vesicles with TIRF microscopy in lung epithelial A549 cells.

Authors: Irina Akopova; Sabina Tatur; Mariusz Grygorczyk; Rafał Luchowski; Ignacy Gryczynski; Zygmunt Gryczynski; Julian Borejdo; Ryszard Grygorczyk
Journal: Purinergic Signal Date: 2011-09-01 Impact factor: 3.765

5. Interaction of purinergic receptors with GPCRs, ion channels, tyrosine kinase and steroid hormone receptors orchestrates cell function.

Authors: Paola Scodelaro Bilbao; Sebastián Katz; Ricardo Boland
Journal: Purinergic Signal Date: 2011-09-02 Impact factor: 3.765

Review 6. Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.

Authors: Maria Serena Longhi; Simon C Robson; Steven H Bernstein; Sara Serra; Silvia Deaglio
Journal: J Mol Med (Berl) Date: 2013-01-06 Impact factor: 4.599