BACKGROUND: We tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade. METHODS:Ninety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia. RESULTS:Duration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h for clonidine with bupivacaine vs 14 +/- 7 h for IM clonidine and 15 +/- 7 h for control, P = 0.016 for control vs clonidine with bupivacaine). Pain scores, analgesic use, and side effects attributable to pain management were similar among groups. CONCLUSIONS:Clonidine significantly prolongs the analgesic durationafter popliteal fossa nerve blockade with bupivacaine.
RCT Entities:
BACKGROUND: We tested the hypothesis that 100 microg clonidine added to 0.375% bupivacaine would prolong the duration of analgesia from popliteal fossa nerve blockade. METHODS: Ninety-nine patients scheduled for hospital admission after foot or ankle surgery entered this randomized, double-blind, placebo-controlled trial. Patients received a popliteal fossa block (nerve stimulator technique, via the posterior approach) using 30 mL 0.375% bupivacaine, with epinephrine. Patients were randomized to receive no clonidine, 100 microg clonidine IM, or 100 microg clonidine with bupivacaine for the popliteal block. Patients also received a combined spinal-epidural anesthetic, a saphenous nerve block, and postoperative IV patient-controlled analgesia. The primary outcome was patient-reported duration of analgesia. RESULTS: Duration of analgesia was statistically longer in the block clonidine group (18 +/- 6 h for clonidine with bupivacaine vs 14 +/- 7 h for IM clonidine and 15 +/- 7 h for control, P = 0.016 for control vs clonidine with bupivacaine). Pain scores, analgesic use, and side effects attributable to pain management were similar among groups. CONCLUSIONS:Clonidine significantly prolongs the analgesic duration after popliteal fossa nerve blockade with bupivacaine.
Authors: Jacques T YaDeau; Leonardo Paroli; Kara G Fields; Richard L Kahn; Vincent R LaSala; Kethy M Jules-Elysee; David H Kim; Stephen C Haskins; Jacob Hedden; Amanda Goon; Matthew M Roberts; David S Levine Journal: Reg Anesth Pain Med Date: 2015 Jul-Aug Impact factor: 6.288
Authors: Jacques T YaDeau; Michael A Gordon; Enrique A Goytizolo; Yi Lin; Kara G Fields; Amanda K Goon; Guilherme Holck; Timothy W Miu; Lawrence V Gulotta; David M Dines; Edward V Craig Journal: Pain Med Date: 2015-12-14 Impact factor: 3.750
Authors: Richard L Kahn; Scott J Ellis; Jennifer Cheng; Jodie Curren; Kara G Fields; Matthew M Roberts; Jacques T YaDeau Journal: HSS J Date: 2017-12-07
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