Literature DB >> 18499454

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Suresh K Tipparaju1, Sipak Joyasawal, Sara Forrester, Debbie C Mulhearn, Scott Pegan, Michael E Johnson, Andrew D Mesecar, Alan P Kozikowski.   

Abstract

Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18499454      PMCID： PMC2526048          DOI： 10.1016/j.bmcl.2008.05.004

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.

Authors:  J W Campbell; J E Cronan
Journal:  Annu Rev Microbiol       Date:  2001       Impact factor: 15.500

Review 2.  Forty years of bacterial fatty acid synthesis.

Authors:  Charles O Rock; Suzanne Jackowski
Journal:  Biochem Biophys Res Commun       Date:  2002-04-19       Impact factor: 3.575

Review 3.  Fatty acid synthase, a proficient multifunctional enzyme.

Authors:  S J Wakil
Journal:  Biochemistry       Date:  1989-05-30       Impact factor: 3.162

Review 4.  Interactions with aromatic rings in chemical and biological recognition.

Authors:  Emmanuel A Meyer; Ronald K Castellano; François Diederich
Journal:  Angew Chem Int Ed Engl       Date:  2003-03-17       Impact factor: 15.336

5.  Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

Authors:  R McLeod; S P Muench; J B Rafferty; D E Kyle; E J Mui; M J Kirisits; D G Mack; C W Roberts; B U Samuel; R E Lyons; M Dorris; W K Milhous; D W Rice
Journal:  Int J Parasitol       Date:  2001-02       Impact factor: 3.981

Review 6.  Lipid biosynthesis as a target for antibacterial agents.

Authors:  R J Heath; S W White; C O Rock
Journal:  Prog Lipid Res       Date:  2001-11       Impact factor: 16.195

7.  A study of the structure-activity relationship for diazaborine inhibition of Escherichia coli enoyl-ACP reductase.

Authors:  C W Levy; C Baldock; A J Wallace; S Sedelnikova; R C Viner; J M Clough; A R Stuitje; A R Slabas; D W Rice; J B Rafferty
Journal:  J Mol Biol       Date:  2001-05-25       Impact factor: 5.469

8.  Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Authors:  D A Rozwarski; G A Grant; D H Barton; W R Jacobs; J C Sacchettini
Journal:  Science       Date:  1998-01-02       Impact factor: 47.728

9.  Phenylimidazole derivatives of 4-pyridone as dual inhibitors of bacterial enoyl-acyl carrier protein reductases FabI and FabK.

Authors:  Hideo Kitagawa; Tomohiro Ozawa; Sho Takahata; Maiko Iida; Jun Saito; Mototsugu Yamada
Journal:  J Med Chem       Date:  2007-08-22       Impact factor: 7.446

10.  Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions.

Authors:  Li-Quan Wang; Charles N Falany; Margaret O James
Journal:  Drug Metab Dispos       Date:  2004-07-21       Impact factor: 3.922
View more
  9 in total

1.  Structure of the Yersinia pestis FabV enoyl-ACP reductase and its interaction with two 2-pyridone inhibitors.

Authors:  Maria W Hirschbeck; Jochen Kuper; Hao Lu; Nina Liu; Carla Neckles; Sonam Shah; Steffen Wagner; Christoph A Sotriffer; Peter J Tonge; Caroline Kisker
Journal:  Structure       Date:  2012-01-11       Impact factor: 5.006

Review 2.  Structural approaches to pathway-specific antimicrobial agents.

Authors:  Michael E Johnson; Leslie W-M Fung
Journal:  Transl Res       Date:  2020-02-06       Impact factor: 7.012

3.  Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.

Authors:  Suresh K Tipparaju; Stephen P Muench; Ernest J Mui; Sergey N Ruzheinikov; Jeffrey Z Lu; Samuel L Hutson; Michael J Kirisits; Sean T Prigge; Craig W Roberts; Fiona L Henriquez; Alan P Kozikowski; David W Rice; Rima L McLeod
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

4.  Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Authors:  Suresh K Tipparaju; Debbie C Mulhearn; Gary M Klein; Yufeng Chen; Subhasish Tapadar; Molly H Bishop; Shuo Yang; Juan Chen; Mahmood Ghassemi; Bernard D Santarsiero; James L Cook; Mary Johlfs; Andrew D Mesecar; Michael E Johnson; Alan P Kozikowski
Journal:  ChemMedChem       Date:  2008-08       Impact factor: 3.466

5.  Structural studies of shikimate dehydrogenase from Bacillus anthracis complexed with cofactor NADP.

Authors:  Guy Barros Barcellos; Rafael Andrade Caceres; Walter Filgueira de Azevedo
Journal:  J Mol Model       Date:  2008-11-29       Impact factor: 1.810

6.  Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.

Authors:  Songpo Guo; Suresh K Tipparaju; Scott D Pegan; Baojie Wan; Shunyan Mo; Jimmy Orjala; Andrew D Mesecar; Scott G Franzblau; Alan P Kozikowski
Journal:  Bioorg Med Chem       Date:  2009-09-04       Impact factor: 3.641

7.  Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

Authors:  Johannes Schiebel; Andrew Chang; Sonam Shah; Yang Lu; Li Liu; Pan Pan; Maria W Hirschbeck; Mona Tareilus; Sandra Eltschkner; Weixuan Yu; Jason E Cummings; Susan E Knudson; Gopal R Bommineni; Stephen G Walker; Richard A Slayden; Christoph A Sotriffer; Peter J Tonge; Caroline Kisker
Journal:  J Biol Chem       Date:  2014-04-16       Impact factor: 5.157

Review 8.  Diversity in enoyl-acyl carrier protein reductases.

Authors:  R P Massengo-Tiassé; J E Cronan
Journal:  Cell Mol Life Sci       Date:  2009-05       Impact factor: 9.261

9.  Rational design and synthesis of novel diphenyl ether derivatives as antitubercular agents.

Authors:  Sidhartha S Kar; Varadaraj Bhat G; Praveen Pn Rao; Vishnu P Shenoy; Indira Bairy; G Gautham Shenoy
Journal:  Drug Des Devel Ther       Date:  2016-07-18       Impact factor: 4.162
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.