Literature DB >> 18498854

Treating heparin resistance with antithrombin or fresh frozen plasma.

Bruce D Spiess1.   

Abstract

Heparin resistance occurs in up to 22% of patients undergoing cardiac surgery requiring cardiopulmonary bypass and it is associated with decreased levels of antithrombin. Treatment options for heparin resistance include administration of antithrombin or fresh frozen plasma. A systematic review revealed no clinical trials directly comparing antithrombin with fresh frozen plasma as heparin resistance treatment during cardiopulmonary bypass. Thus, the aim of this review is to discuss the limited number of published reports assessing antithrombin or fresh frozen plasma in managing heparin resistance and to present emerging data regarding fresh frozen plasma safety issues and practical considerations for antithrombin treatment in patients with heparin resistance undergoing cardiopulmonary bypass.

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Year:  2008        PMID： 18498854     DOI： 10.1016/j.athoracsur.2008.02.037

Source DB:  PubMed          Journal:  Ann Thorac Surg        ISSN： 0003-4975            Impact factor:   4.330


  20 in total

1.  Apparent heparin resistance in a patient with infective endocarditis secondary to elevated factor VIII levels.

Authors:  Ramya Thota; Apar Kishor Ganti; Shanmuga Subbiah
Journal:  J Thromb Thrombolysis       Date:  2012-07       Impact factor: 2.300

Review 2.  Clinical use and the Italian demand for antithrombin.

Authors:  Giancarlo M Liumbruno; Massimo Franchini; Monica Lanzoni; Fabio Candura; Stefania Vaglio; Samantha Profili; Liviana Catalano; Giuseppina Facco; Simonetta Pupella; Gabriele Calizzani; Giuliano Grazzini
Journal:  Blood Transfus       Date:  2013-09       Impact factor: 3.443

3.  Supplementation with antithrombin III ex vivo optimizes enoxaparin responses in critically injured patients.

Authors:  Jessica C Cardenas; Yao-Wei Wang; Jay V Karri; Seenya Vincent; Andrew P Cap; Bryan A Cotton; Charles E Wade
Journal:  Thromb Res       Date:  2020-01-15       Impact factor: 3.944

Review 4.  Is there evidence that fresh frozen plasma is superior to antithrombin administration to treat heparin resistance in cardiac surgery?

Authors:  Gwyn W Beattie; Robert R Jeffrey
Journal:  Interact Cardiovasc Thorac Surg       Date:  2013-09-07

5.  The Impact of Antithrombin III Use in Achieving Anticoagulant Goals in Pediatric Patients.

Authors:  Allison J Jones; Keliana L O'Mara; Brian J Kelly; Ravi S Samraj
Journal:  J Pediatr Pharmacol Ther       Date:  2017 Sep-Oct

6.  Successful treatment of a massive pulmonary embolism using rivaroxaban in a patient with antithrombin III deficiency.

Authors:  Junji Yamaguchi; Nobuhiro Hara; Tetsuo Yamaguchi; Yasutoshi Nagata; Toshihiro Nozato; Takamichi Miyamoto
Journal:  J Cardiol Cases       Date:  2017-07-26

7.  Antithrombin Administration During Intravenous Heparin Anticoagulation in the Intensive Care Unit: A Single-Center Matched Retrospective Cohort Study.

Authors:  Jacob T Beyer; Kelly E Schoeppler; Giorgio Zanotti; Gregory M Weiss; Scott W Mueller; Robert MacLaren; Douglas N Fish; Tyree H Kiser
Journal:  Clin Appl Thromb Hemost       Date:  2016-09-13       Impact factor: 2.389

Review 8.  [Heparin resistance and antithrombin deficiency].

Authors:  Norbert Maurin
Journal:  Med Klin (Munich)       Date:  2009-06-16

9.  Heparin Resistance and Anticoagulation Failure in a Challenging Case of Cerebral Venous Sinus Thrombosis.

Authors:  Adam B King; Anne E O'Duffy; Avinash B Kumar
Journal:  Neurohospitalist       Date:  2015-06-19

10.  Successful anticoagulation with fresh frozen plasma for cardiopulmonary bypass in a patient with heparin resistance: a cautionary tale.

Authors:  Omar Badrin; Suana Kushairi; Zuhrah Zakaria; Anand Sachithanandan
Journal:  BMJ Case Rep       Date:  2013-04-29
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