OBJECTIVE: Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design. METHOD: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins. RESULTS: Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins. CONCLUSION: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could reflect common aetiological factors contributing to each of the disorders. Future studies should attempt to investigate the relative genetic and environmental contribution to the shared risk factors for schizophrenia, mood and anxiety disorders.
OBJECTIVE:Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design. METHOD: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins. RESULTS:Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins. CONCLUSION: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could reflect common aetiological factors contributing to each of the disorders. Future studies should attempt to investigate the relative genetic and environmental contribution to the shared risk factors for schizophrenia, mood and anxiety disorders.
Authors: Krista M Wisner; Brita Elvevåg; James M Gold; Daniel R Weinberger; Dwight Dickinson Journal: Schizophr Res Date: 2010-10-28 Impact factor: 4.939
Authors: K L Musliner; B B Trabjerg; B L Waltoft; T M Laursen; P B Mortensen; P P Zandi; T Munk-Olsen Journal: Psychol Med Date: 2015-04-29 Impact factor: 7.723
Authors: Marco M Picchioni; Fruhling Rijsdijk; Timothea Toulopoulou; Christopher Chaddock; James H Cole; Ulrich Ettinger; Ana Oses; Hugo Metcalfe; Robin M Murray; Philip McGuire Journal: J Psychiatry Neurosci Date: 2017-03 Impact factor: 6.186
Authors: Mandy Meijer; Arlin Keo; Judith M C van Leeuwen; Oleh Dzyubachyk; Onno C Meijer; Christiaan H Vinkers; Ahmed Mahfouz Journal: Neurobiol Stress Date: 2021-02-10