BACKGROUND: In patients with the cerebellar variant of multiple system atrophy (MSA-C), reduced fractional anisotropy (FA) has been reported in several brain areas. However, since previous studies have employed predetermined regions of interest (ROI), the brain areas showing the earliest alterations in FA are unknown. The sensitivity of detecting early-stage MSA-C and the time course of the FA reduction are also unknown. The purpose was to address these issues to determine the diagnostic value of FA for early diagnosis. METHODS: Twenty-one patients with MSA-C were investigated. Voxel-based FA analysis and morphometry were used to detect the differences between early-stage MSA-C and normal controls. An ROI-based FA analysis was also used to clarify the temporal profile. RESULTS: From the early-stage, MSA-C patients exhibited reduced FA and white matter atrophy in the middle cerebellar peduncle, the inferior cerebellar peduncle, and the ventral pons. The FA of these areas decreased rapidly during the first few years after onset, after which a rather gradual reduction occurred. The receiver operating characteristics analysis revealed a high sensitivity and specificity for discriminating early MSA-C from normal controls. CONCLUSIONS: FA measurement could potentially be used to make an early diagnosis and monitor progression in MSA-C patients.
BACKGROUND: In patients with the cerebellar variant of multiple system atrophy (MSA-C), reduced fractional anisotropy (FA) has been reported in several brain areas. However, since previous studies have employed predetermined regions of interest (ROI), the brain areas showing the earliest alterations in FA are unknown. The sensitivity of detecting early-stage MSA-C and the time course of the FA reduction are also unknown. The purpose was to address these issues to determine the diagnostic value of FA for early diagnosis. METHODS: Twenty-one patients with MSA-C were investigated. Voxel-based FA analysis and morphometry were used to detect the differences between early-stage MSA-C and normal controls. An ROI-based FA analysis was also used to clarify the temporal profile. RESULTS: From the early-stage, MSA-C patients exhibited reduced FA and white matter atrophy in the middle cerebellar peduncle, the inferior cerebellar peduncle, and the ventral pons. The FA of these areas decreased rapidly during the first few years after onset, after which a rather gradual reduction occurred. The receiver operating characteristics analysis revealed a high sensitivity and specificity for discriminating early MSA-C from normal controls. CONCLUSIONS: FA measurement could potentially be used to make an early diagnosis and monitor progression in MSA-C patients.
Authors: Martina Minnerop; Eileen Lüders; Karsten Specht; Jürgen Ruhlmann; Nicole Schimke; Paul M Thompson; Yi Y Chou; Arthur W Toga; Michael Abele; Ullrich Wüllner; Thomas Klockgether Journal: Mov Disord Date: 2010-11-15 Impact factor: 10.338
Authors: Kenichi Oishi; Andreia Faria; Hangyi Jiang; Xin Li; Kazi Akhter; Jiangyang Zhang; John T Hsu; Michael I Miller; Peter C M van Zijl; Marilyn Albert; Constantine G Lyketsos; Roger Woods; Arthur W Toga; G Bruce Pike; Pedro Rosa-Neto; Alan Evans; John Mazziotta; Susumu Mori Journal: Neuroimage Date: 2009-06 Impact factor: 6.556
Authors: Aaron Michael Rulseh; Jiri Keller; Jan Rusz; Michael Syka; Hana Brozova; Robert Rusina; Petra Havrankova; Katerina Zarubova; Hana Malikova; Robert Jech; Josef Vymazal Journal: Neuropsychiatr Dis Treat Date: 2016-08-26 Impact factor: 2.570