Literature DB >> 18497999

Molecular evidence for apoptosis in microfilariae of Wuchereria bancrofti induced by diethylcarbamazine.

C A Peixoto1, A C O Santos, C F J Ayres.   

Abstract

Apoptosis, a programmed cell death, is characterized by chromatin condensation, numerous vacuoles, reduction in cell volume, and endonuclease cleavage DNA degradation detected in gel electrophoresis as nucleosomal ladder. Here we report that diethylcarbamazine induces DNA fragmentation in microfilariae of Wuchereria bancrofti revealed by ligation-mediated polymerase chain reaction and by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling at the light and electron transmission level.

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Year:  2008        PMID： 18497999     DOI： 10.1007/s00436-008-1020-6

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  30 in total

Review 1.  Microtubule-interacting drugs for cancer treatment.

Authors:  Paula M Checchi; James H Nettles; Jun Zhou; James P Snyder; Harish C Joshi
Journal:  Trends Pharmacol Sci       Date:  2003-07       Impact factor: 14.819

2.  DEC-inhibited development of third-stage Brugia pahangi in vitro.

Authors:  Y Fujimaki; M Shimada; E Kimura; Y Aoki
Journal:  Parasitol Res       Date:  1988       Impact factor: 2.289

3.  Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis.

Authors:  T V Rajan; L D Shultz; S Babu; J Doukas; D Greiner; P Porte
Journal:  Exp Parasitol       Date:  1998-03       Impact factor: 2.011

4.  Diethylcarbamazine, antifilarial drug, inhibits microtubule polymerization and disrupts preformed microtubules.

Authors:  Y Fujimaki; M Ehara; E Kimura; M Shimada; Y Aoki
Journal:  Biochem Pharmacol       Date:  1990-03-01       Impact factor: 5.858

5.  Pharmacokinetics of diethylcarbamazine after single oral dose at two different times of day in human subjects.

Authors:  Sambamoorthy Bolla; Ramesh R Boinpally; Srinivasu Poondru; Rambhau Devaraj; Bhaskara R Jasti
Journal:  J Clin Pharmacol       Date:  2002-03       Impact factor: 3.126

6.  Diethylcarbamazine induces loss of microfilarial sheath of Wuchereria bancrofti.

Authors:  C A Peixoto; L C Alves; F A Brayner; M S Florêncio
Journal:  Micron       Date:  2003       Impact factor: 2.251

7.  The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti.

Authors:  M S Florêncio; C A Peixoto
Journal:  Parasitology       Date:  2003-06       Impact factor: 3.234

8.  Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-beta 1 occurs without activation of an endonuclease.

Authors:  F Oberhammer; G Fritsch; M Pavelka; G Froschl; R Tiefenbacher; T Purchio; R Schulte-Hermann
Journal:  Toxicol Lett       Date:  1992-12       Impact factor: 4.372

9.  Biochemical evidence for programmed cell death in rabbit uterine epithelium.

Authors:  R J Rotello; M B Hocker; L E Gerschenson
Journal:  Am J Pathol       Date:  1989-03       Impact factor: 4.307

Review 10.  Diethylcarbamazine (DEC): immunopharmacological interactions of an anti-filarial drug.

Authors:  R M Maizels; D A Denham
Journal:  Parasitology       Date:  1992       Impact factor: 3.234
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  6 in total

1.  Role of Glutathione in Chalcone Derivative Induced Apoptosis of Brugia malayi and its Possible Therapeutic Implication.

Authors:  P S Bhoj; S Bahekar; V Khatri; N Singh; N S Togre; K Goswami; H S Chandak; D Dash
Journal:  Acta Parasitol       Date:  2020-10-10       Impact factor: 1.440

2.  The Role of Oxidative and Nitrosative Stress of Silver Nanoparticles in Human Parasitic Helminth Brugia malayi: A Mechanistic Insight.

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3.  Expression profile of genes during resistance reversal in a temephos selected strain of the dengue vector, Aedes aegypti.

Authors:  Clare Strode; Maria de Melo-Santos; Tereza Magalhães; Ana Araújo; Contancia Ayres
Journal:  PLoS One       Date:  2012-08-01       Impact factor: 3.240

4.  Current evidence on the use of antifilarial agents in the management of bancroftian filariasis.

Authors:  Sumadhya Deepika Fernando; Chaturaka Rodrigo; Senaka Rajapakse
Journal:  J Trop Med       Date:  2010-12-30

5.  Novel microfilaricidal activity of nanosilver.

Authors:  Sunil K Singh; Kalyan Goswami; Richa D Sharma; Maryada V R Reddy; Debabrata Dash
Journal:  Int J Nanomedicine       Date:  2012-02-22

6.  Therapy and Prevention for Human Toxocariasis.

Authors:  Jean-François Magnaval; Emilie Bouhsira; Judith Fillaux
Journal:  Microorganisms       Date:  2022-01-22
  6 in total

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