BACKGROUND: The etiology of Hyperemesis gravidarum (HG) is unclear. To test the hypothesis of an association between Helicobacter pylori infection and HG, an institution-based case-control study was performed at Aker University Hospital (AUH) during 1994-1999. MATERIAL AND METHOD: From the same source population, 244 incident cases of HG and 244 pregnant women free of the disease (controls) were consecutively identified. RESULTS: H. pylori were noted in 105 cases and 58 control subjects. The presence of H. pylori increased the risk of HG more than two fold (OR = 2.42, 95% CI: 1.64-3.57, P < 0.001). This association was much stronger in Africans as compared to non-Africans (OR = 5.26, 95% CI: 1.04-26.57 vs. OR = 1.67, 95% CI: 1.07-2.61) after controlling for the confounding effect of maternal age. A gradient effect of exposure to H. pylori, determined by presence of specific IgG antibody in serum, and increased frequency of HG was present in Africans (test for linear trend P = 0.05) and non-Africans (test for linear trend P = 0.004). CONCLUSION: These results indicate that H. pylori increase the risk of HG with a dose-response pattern and stronger in Africans.
BACKGROUND: The etiology of Hyperemesis gravidarum (HG) is unclear. To test the hypothesis of an association between Helicobacter pyloriinfection and HG, an institution-based case-control study was performed at Aker University Hospital (AUH) during 1994-1999. MATERIAL AND METHOD: From the same source population, 244 incident cases of HG and 244 pregnant women free of the disease (controls) were consecutively identified. RESULTS:H. pylori were noted in 105 cases and 58 control subjects. The presence of H. pylori increased the risk of HG more than two fold (OR = 2.42, 95% CI: 1.64-3.57, P < 0.001). This association was much stronger in Africans as compared to non-Africans (OR = 5.26, 95% CI: 1.04-26.57 vs. OR = 1.67, 95% CI: 1.07-2.61) after controlling for the confounding effect of maternal age. A gradient effect of exposure to H. pylori, determined by presence of specific IgG antibody in serum, and increased frequency of HG was present in Africans (test for linear trend P = 0.05) and non-Africans (test for linear trend P = 0.004). CONCLUSION: These results indicate that H. pylori increase the risk of HG with a dose-response pattern and stronger in Africans.
Authors: F Lerang; J B Haug; B Moum; P Mowinckel; T Berge; E Ragnhildstveit; A Bjørneklett Journal: Scand J Gastroenterol Date: 1998-07 Impact factor: 2.423
Authors: R Sinan Karadeniz; Ozlem Ozdegirmenci; M Metin Altay; Ayse Solaroglu; Serdar Dilbaz; Nedret Hizel; Ali Haberal Journal: Infect Dis Obstet Gynecol Date: 2006
Authors: Vincent W V Jaddoe; Cock M van Duijn; Albert J van der Heijden; Johan P Mackenbach; Henriëtte A Moll; Eric A P Steegers; Henning Tiemeier; Andre G Uitterlinden; Frank C Verhulst; Albert Hofman Journal: Eur J Epidemiol Date: 2010-10-22 Impact factor: 8.082
Authors: Iris J Grooten; Ben W Mol; Joris A M van der Post; Carrie Ris-Stalpers; Marjolein Kok; Joke M J Bais; Caroline J Bax; Johannes J Duvekot; Henk A Bremer; Martina M Porath; Wieteke M Heidema; Kitty W M Bloemenkamp; Hubertina C J Scheepers; Maureen T M Franssen; Martijn A Oudijk; Tessa J Roseboom; Rebecca C Painter Journal: BMC Pregnancy Childbirth Date: 2016-01-27 Impact factor: 3.007