Literature DB >> 184932

Genes responsible for transformation by avian RNA tumor viruses.

J M Coffin.   

Abstract

Avian sarcoma viruses probably contain 4 genes. One of these, src, controls the process of transformation of the infected cell and has been located near the 3' end of the viral genome. The remaining 3 genes direct the synthesis of virion proteins: env (envelope proteins), pol (polymerase), and gag (internal proteins). They are probably in the order gag-poly-env-src. A scheme for the replication of these viruses is proposed, and several possible mechanisms for their origin and variability are discussed.

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Year:  1976        PMID： 184932

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  5 in total

1.  New procedure for isolation of Rous sarcoma virus-specific RNA from infected cells.

Authors:  P A Bromley; P F Spahr; J L Darlix
Journal:  J Virol       Date:  1979-07       Impact factor: 5.103

2.  Multiple forms of sarc gene proteins from Rous sarcoma virus RNA.

Authors:  J Kamine; J G Burr; J M Buchanan
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

3.  Nucleotide sequence relationships between the genomes of an endogenous and an exogenous avian tumor virus.

Authors:  J M Coffin; M Champion; F Chabot
Journal:  J Virol       Date:  1978-12       Impact factor: 5.103

4.  Unwinding-like activity associated with avian retrovirus RNA-directed DNA polymerase.

Authors:  M S Collett; J P Leis; M S Smith; A J Faras
Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

5.  Target cell specificity of defective avian leukemia viruses: hematopoietic target cells for a given virus type can be infected but not transformed by strains of a different type.

Authors:  T Graf; H Beug; M J Hayman
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205
  5 in total

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