BACKGROUND/AIMS: Obesity is linked to metabolic complications, even in children, but the role of the distribution of adiposity is unclear. We aimed to assess which compartment of fat mass - total (TFM), visceral (VFM) or subcutaneous (SCFM)--is related to metabolic complications in overweight and obese children and adolescents. DESIGN: Analyses were conducted in 159 overweight or obese children and adolescents (median body mass index 4.0 SD). TFM was measured by dual-energy x-ray absorptiometry. Distribution of abdominal fat was assessed by MRI. Insulin resistance (IR) was determined using a homeostatic model assessment. The definition of metabolic syndrome (MS) was derived from National Cholesterol Education Program ATP III. RESULTS: A parental history of obesity was positively and significantly associated with fat content of the three compartments (TFM: beta = 2.22; VFM: beta = 0.17; SCFM: beta = 0.12, respectively). VFM was also associated with gender (beta = -0.29) and ethnicity (beta = -0.54). TFM was a significant and independent determinant of IR (beta = 0.02) whereas IR and VFM only were significantly related to MS (OR = 3.55 and 3.66 respectively). CONCLUSION: Our data indicate that even in overweight children VFM was influenced by several factors such as sex and ethnicity and that a relationship was evidenced between the amount of VFM and MS. Copyright 2008 S. Karger AG, Basel.
BACKGROUND/AIMS: Obesity is linked to metabolic complications, even in children, but the role of the distribution of adiposity is unclear. We aimed to assess which compartment of fat mass - total (TFM), visceral (VFM) or subcutaneous (SCFM)--is related to metabolic complications in overweight and obesechildren and adolescents. DESIGN: Analyses were conducted in 159 overweight or obesechildren and adolescents (median body mass index 4.0 SD). TFM was measured by dual-energy x-ray absorptiometry. Distribution of abdominal fat was assessed by MRI. Insulin resistance (IR) was determined using a homeostatic model assessment. The definition of metabolic syndrome (MS) was derived from National Cholesterol Education Program ATP III. RESULTS: A parental history of obesity was positively and significantly associated with fat content of the three compartments (TFM: beta = 2.22; VFM: beta = 0.17; SCFM: beta = 0.12, respectively). VFM was also associated with gender (beta = -0.29) and ethnicity (beta = -0.54). TFM was a significant and independent determinant of IR (beta = 0.02) whereas IR and VFM only were significantly related to MS (OR = 3.55 and 3.66 respectively). CONCLUSION: Our data indicate that even in overweight children VFM was influenced by several factors such as sex and ethnicity and that a relationship was evidenced between the amount of VFM and MS. Copyright 2008 S. Karger AG, Basel.
Authors: Jacquelyn A Hatch-Stein; Andrea Kelly; Samuel S Gidding; Babette S Zemel; Sheela N Magge Journal: J Clin Lipidol Date: 2016-02-16 Impact factor: 4.766
Authors: David E Brumbaugh; Phillip Tearse; Melanie Cree-Green; Laura Z Fenton; Mark Brown; Ann Scherzinger; Regina Reynolds; Meredith Alston; Camille Hoffman; Zhaoxing Pan; Jacob E Friedman; Linda A Barbour Journal: J Pediatr Date: 2012-12-20 Impact factor: 4.406
Authors: Diane H Fredrikson; Heidi N Boyda; Lurdes Tse; Zachary Whitney; Mark A Pattison; Fred J Ott; Laura Hansen; Alasdair M Barr Journal: Front Psychiatry Date: 2014-09-05 Impact factor: 4.157