Literature DB >> 1849233

Primary structure and functional expression from complementary DNA of a brain calcium channel.

Y Mori1, T Friedrich, M S Kim, A Mikami, J Nakai, P Ruth, E Bosse, F Hofmann, V Flockerzi, T Furuichi.   

Abstract

The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

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Year:  1991        PMID： 1849233     DOI： 10.1038/350398a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  207 in total

1.  Allosteric modulation of Ca2+ channels by G proteins, voltage-dependent facilitation, protein kinase C, and Ca(v)beta subunits.

Authors:  S Herlitze; H Zhong; T Scheuer; W A Catterall
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-10       Impact factor: 11.205

2.  Properties of Q-type calcium channels in neostriatal and cortical neurons are correlated with beta subunit expression.

Authors:  P G Mermelstein; R C Foehring; T Tkatch; W J Song; G Baranauskas; D J Surmeier
Journal:  J Neurosci       Date:  1999-09-01       Impact factor: 6.167

3.  Biphasic, opposing modulation of cloned neuronal alpha1E Ca channels by distinct signaling pathways coupled to M2 muscarinic acetylcholine receptors.

Authors:  U Meza; R Bannister; K Melliti; B Adams
Journal:  J Neurosci       Date:  1999-08-15       Impact factor: 6.167

4.  Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit.

Authors:  K Jun; E S Piedras-Rentería; S M Smith; D B Wheeler; S B Lee; T G Lee; H Chin; M E Adams; R H Scheller; R W Tsien; H S Shin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

5.  Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca2+ channel gating.

Authors:  Thomas D Helton; William A Horne
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

6.  Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies.

Authors:  Sandrine Geib; Guillaume Sandoz; Kamel Mabrouk; Alessandra Matavel; Pascale Marchot; Toshinori Hoshi; Michel Villaz; Michel Ronjat; Raymond Miquelis; Christian Lévêque; Michel de Waard
Journal:  Biochem J       Date:  2002-05-15       Impact factor: 3.857

7.  Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons.

Authors:  Jakob Wolfart; Jochen Roeper
Journal:  J Neurosci       Date:  2002-05-01       Impact factor: 6.167

8.  Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release.

Authors:  M Okada; D J Nutt; T Murakami; G Zhu; A Kamata; Y Kawata; S Kaneko
Journal:  J Neurosci       Date:  2001-01-15       Impact factor: 6.167

9.  Modulation of slow inactivation in class A Ca2+ channels by beta-subunits.

Authors:  S Sokolov; R G Weiss; E N Timin; S Hering
Journal:  J Physiol       Date:  2000-09-15       Impact factor: 5.182

10.  Auxiliary subunits operate as a molecular switch in determining gating behaviour of the unitary N-type Ca2+ channel current in Xenopus oocytes.

Authors:  M Wakamori; G Mikala; Y Mori
Journal:  J Physiol       Date:  1999-06-15       Impact factor: 5.182
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