| Literature DB >> 18491860 |
Maja Majerić Elenkov1, Lixia Tang, Auke Meetsma, Bernhard Hauer, Dick B Janssen.
Abstract
Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.Entities:
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Year: 2008 PMID： 18491860 DOI： 10.1021/ol800698t
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005