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Literature DB >> 1849126

Ocular toxicity of experimental intravitreal itraconazole.

J A Schulman¹, G A Peyman, J Dietlein, R Fiscella.

Abstract

We investigated itraconazole, a new triazole antifungal agent that poorly penetrates ocular tissues after oral administration. We injected itraconazole in doses from 10 to 100 micrograms dissolved in 100% dimethyl sulfoxide into the eyes of New Zealand rabbits. Ocular toxicity studies performed five weeks after administration showed no substantial retinal or histopathologic changes in eyes injected with either 100% dimethyl sulfoxide or 10 micrograms of itraconazole. Higher doses caused focal areas of retinal necrosis. Our results indicated that intravitreal doses of 10 micrograms or less of itraconazole may be beneficial in the treatment of fungal endophthalmitis.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1849126 DOI： 10.1007/bf00150975

Source DB: PubMed Journal: Int Ophthalmol ISSN： 0165-5701 Impact factor: 2.031

15 in total

1. Exogenous intraocular fungus infections with particular reference to complications of intraocular surgery.

Authors: B S FINE; L E ZIMMERMAN
Journal: Am J Ophthalmol Date: 1959-08 Impact factor: 5.258

2. OCULAR PENETRATION OF AMPHOTERICIN B: A REPORT OF LABORATORY STUDIES AND A CASE REPORT OF POSTSURGICAL CEPHALOSPORIUM ENDOPHTHALMITIS.

Authors: W R GREEN; J E BENNETT; R D GOOS
Journal: Arch Ophthalmol Date: 1965-06

3. The activity of ketoconazole and itraconazole against Aspergillus fumigatus in mixed cultures with macrophages or leukocytes.

Authors: F Aerts; J Van Cutsem; M De Brabander
Journal: Mykosen Date: 1986-04

4. Intravitreal amphotericin B toxicity.

Authors: E N Souri; W R Green
Journal: Am J Ophthalmol Date: 1974-07 Impact factor: 5.258

5. Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.

Authors: J D Sobel; G Muller
Journal: Antimicrob Agents Chemother Date: 1984-08 Impact factor: 5.191

6. Itraconazole in the treatment of human mycoses: review of three years of clinical experience.

Authors: G Cauwenbergh; P De Doncker; K Stoops; A M De Dier; H Goyvaerts; V Schuermans
Journal: Rev Infect Dis Date: 1987 Jan-Feb

7. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.

Authors: J R Perfect; D V Savani; D T Durack
Journal: Antimicrob Agents Chemother Date: 1986-04 Impact factor: 5.191

8. Toxicity of intravitreous miconazole.

Authors: F I Tolentino; C S Foster; M Lahav; L H Liu; A R Rabin
Journal: Arch Ophthalmol Date: 1982-09

9. Correlation of susceptibility test results in vitro with response in vivo: ketoconazole therapy in a systemic candidiasis model.

Authors: A Polak; F C Odds; E Lüdin; H J Scholer
Journal: Chemotherapy Date: 1985 Impact factor: 2.544

Ocular toxicity of experimental intravitreal itraconazole.

1. Exogenous intraocular fungus infections with particular reference to complications of intraocular surgery.

2. OCULAR PENETRATION OF AMPHOTERICIN B: A REPORT OF LABORATORY STUDIES AND A CASE REPORT OF POSTSURGICAL CEPHALOSPORIUM ENDOPHTHALMITIS.

3. The activity of ketoconazole and itraconazole against Aspergillus fumigatus in mixed cultures with macrophages or leukocytes.

4. Intravitreal amphotericin B toxicity.

5. Comparison of itraconazole and ketoconazole in the treatment of experimental candidal vaginitis.

6. Itraconazole in the treatment of human mycoses: review of three years of clinical experience.

7. Comparison of itraconazole and fluconazole in treatment of cryptococcal meningitis and candida pyelonephritis in rabbits.

8. Toxicity of intravitreous miconazole.

9. Correlation of susceptibility test results in vitro with response in vivo: ketoconazole therapy in a systemic candidiasis model.

10. Vitrectomy in experimental endophthalmitis: Part I-Fungal infection.

Review 1. Challenges in the Polyene- and Azole-Based Pharmacotherapy of Ocular Fungal Infections.

Review 2. Current perspectives on ophthalmic mycoses.

3. Dimethyl sulphoxide dose-response on rat retinal function.

4. Intravitreal itraconazole inhibits laser-induced choroidal neovascularization in rats.