Literature DB >> 18490917

Can the immune system be harnessed to repair the CNS?

Phillip G Popovich1, Erin E Longbrake.   

Abstract

Experimental and clinical data have demonstrated that activating the immune system in the CNS can be destructive. However, other studies have shown that enhancing an immune response can be therapeutic, and several clinical trials have been initiated with the aim of boosting immune responses in the CNS of individuals with spinal cord injury, multiple sclerosis and Alzheimer's disease. Here, we evaluate the controversies in the field and discuss the remaining scientific challenges that are associated with enhancing immune function in the CNS to treat neurological diseases.

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Year:  2008        PMID： 18490917     DOI： 10.1038/nrn2398

Source DB:  PubMed          Journal:  Nat Rev Neurosci        ISSN： 1471-003X            Impact factor:   34.870


  122 in total

1.  System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo.

Authors:  Kristina A Kigerl; Daniel P Ankeny; Sanjay K Garg; Ping Wei; Zhen Guan; Wenmin Lai; Dana M McTigue; Ruma Banerjee; Phillip G Popovich
Journal:  Exp Neurol       Date:  2011-11-04       Impact factor: 5.330

Review 2.  Systemic inflammatory cells fight off neurodegenerative disease.

Authors:  Michal Schwartz; Ravid Shechter
Journal:  Nat Rev Neurol       Date:  2010-06-08       Impact factor: 42.937

3.  Neutrophils express oncomodulin and promote optic nerve regeneration.

Authors:  Takuji Kurimoto; Yuqin Yin; Ghaith Habboub; Hui-Ya Gilbert; Yiqing Li; Shintaro Nakao; Ali Hafezi-Moghadam; Larry I Benowitz
Journal:  J Neurosci       Date:  2013-09-11       Impact factor: 6.167

4.  Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice.

Authors:  Camila M Freria; Jodie C E Hall; Ping Wei; Zhen Guan; Dana M McTigue; Phillip G Popovich
Journal:  J Neurosci       Date:  2017-03-06       Impact factor: 6.167

Review 5.  Neuroinflammation and synaptic loss.

Authors:  Jagadeesh S Rao; Matthew Kellom; Hyung-Wook Kim; Stanley I Rapoport; Edmund A Reese
Journal:  Neurochem Res       Date:  2012-02-07       Impact factor: 3.996

6.  Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord.

Authors:  Liang Xu; Chao-jin Xu; He-Zuo Lü; Yan-Xia Wang; Ying Li; Pei-Hua Lu
Journal:  Stem Cell Rev Rep       Date:  2010-03       Impact factor: 5.739

7.  B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice.

Authors:  Daniel P Ankeny; Zhen Guan; Phillip G Popovich
Journal:  J Clin Invest       Date:  2009-09-21       Impact factor: 14.808

8.  Pathogenic antibodies are active participants in spinal cord injury.

Authors:  Gregory A Dekaban; Sakina Thawer
Journal:  J Clin Invest       Date:  2009-09-21       Impact factor: 14.808

Review 9.  The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host's Defense Strategy against Neuroinflammation.

Authors:  Yosra Bedoui; Jim W Neal; Philippe Gasque
Journal:  J Neuroimmune Pharmacol       Date:  2018-06-16       Impact factor: 4.147

10.  Transcriptomic characterization of microglia activation in a rat model of ischemic stroke.

Authors:  Wenjun Deng; Emiri Mandeville; Yasukazu Terasaki; Wenlu Li; Julie Holder; Aaron Tt Chuang; Mingming Ning; Ken Arai; Eng H Lo; Changhong Xing
Journal:  J Cereb Blood Flow Metab       Date:  2020-06-17       Impact factor: 6.200
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