| Literature DB >> 18490798 |
W van der Velden1, J Huussen, H Ter Laak, R de Sévaux.
Abstract
Neuromyopathy is a rare side effect of chronic colchicine therapy, most often occurring in patients with chronic renal failure. Drugs interacting with colchicine metabolism through CYP(3)A(4) and P-glycoprotein can accelerate accumulation and toxicity. We describe a case of an interaction between clarithromycin and colchicine resulting in acute neuromyopathy, and we conclude that combined use of macrolides and colchicine should be avoided.Entities:
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Year: 2008 PMID: 18490798
Source DB: PubMed Journal: Neth J Med ISSN: 0300-2977 Impact factor: 1.422