| Literature DB >> 18490707 |
Eva M Briso1, Oliver Dienz, Mercedes Rincon.
Abstract
IL-6 trans-signaling via the soluble IL-6R (sIL-6R) plays an important role in the progression of several autoimmune diseases and cancer by providing IL-6-responsiveness to cells lacking IL-6R. However, the potential sources of sIL-6R are less understood. In this study we show that sIL-6R is produced by both naive and memory CD4 T cells upon TCR activation. The production of sIL-6R by activated CD4 T cells is mediated by shedding of the membrane-bound IL-6R, and this process correlates with the expression of the metalloproteinase ADAM17 in these cells. In contrast to CD4 T cells, CD8 T cells do not express ADAM17 and their production of sIL-6R is negligible. Thus, during an immune response CD4 T cells are an important source of sIL-6R. Production of sIL-6R by autoreactive CD4 T cells may contribute to their role in the development of autoimmune disease by conferring IL-6-responsiveness to cells lacking IL-6R such as synoviocytes.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18490707 PMCID： PMC2692633 DOI： 10.4049/jimmunol.180.11.7102
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422