BACKGROUND: Vascular depression has been proposed as a unique diagnostic subtype in late life, yet no study has evaluated whether the specified clinical features associated with the illness are jointly indicative of an underlying diagnostic class. METHODS: We applied latent class analysis to two independent clinical samples: the prospective, cohort design, Neurocognitive Outcomes of Depression in the Elderly (NCODE) study and the 8-week, multicenter, double blind, placebo-controlled Old-Old study. RESULTS: A two-class model consisting of vascular and nonvascular depressed patients provided an excellent fit to the data in both studies, chi(2)(6) = 2.02, p = .90 in the NCODE study and chi(2)(6) = 7.024, p = .32 in the Old-Old study. Although all of the proposed features of vascular depression were useful in identifying the illness, deep white matter lesion burden emerged with perfect sensitivity (1.00) and near-perfect specificity (.95), making it the only indicator necessary to determine class membership. CONCLUSIONS: These findings, replicated across two independent clinical samples, provide the first support for the internal validity of vascular depression as a subtype of late-life depression.
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BACKGROUND:Vascular depression has been proposed as a unique diagnostic subtype in late life, yet no study has evaluated whether the specified clinical features associated with the illness are jointly indicative of an underlying diagnostic class. METHODS: We applied latent class analysis to two independent clinical samples: the prospective, cohort design, Neurocognitive Outcomes of Depression in the Elderly (NCODE) study and the 8-week, multicenter, double blind, placebo-controlled Old-Old study. RESULTS: A two-class model consisting of vascular and nonvascular depressedpatients provided an excellent fit to the data in both studies, chi(2)(6) = 2.02, p = .90 in the NCODE study and chi(2)(6) = 7.024, p = .32 in the Old-Old study. Although all of the proposed features of vascular depression were useful in identifying the illness, deep white matter lesion burden emerged with perfect sensitivity (1.00) and near-perfect specificity (.95), making it the only indicator necessary to determine class membership. CONCLUSIONS: These findings, replicated across two independent clinical samples, provide the first support for the internal validity of vascular depression as a subtype of late-life depression.
Authors: Chien-Ti Lee; Jeannie-Marie Leoutsakos; Constantine G Lyketsos; David C Steffens; John C S Breitner; Maria C Norton Journal: Int J Geriatr Psychiatry Date: 2011-12-02 Impact factor: 3.485
Authors: Ruth T Morin; Philip Insel; Craig Nelson; Meryl Butters; David Bickford; Susan Landau; Andrew Saykin; Michael Weiner; R Scott Mackin Journal: J Int Neuropsychol Soc Date: 2019-06-24 Impact factor: 2.892
Authors: Patrick J Brown; Joel R Sneed; Bret R Rutherford; D P Devanand; Steven P Roose Journal: Int J Geriatr Psychiatry Date: 2013-10-03 Impact factor: 3.485