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Literature DB >> 18489257

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.

Martina U Muckenthaler¹, Bruno Galy, Matthias W Hentze.

Abstract

The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18489257 DOI： 10.1146/annurev.nutr.28.061807.155521

Source DB: PubMed Journal: Annu Rev Nutr ISSN： 0199-9885 Impact factor: 11.848

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Cited

242 in total

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Authors: Gabriele Siedenburg; Matthew R Groves; Darío Ortiz de Orué Lucana
Journal: Antioxid Redox Signal Date: 2012-01-06 Impact factor: 8.401

2. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

Authors: Srinivas Chollangi; Joel W Thompson; Julio C Ruiz; Kevin H Gardner; Richard K Bruick
Journal: J Biol Chem Date: 2012-05-30 Impact factor: 5.157

3. Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages.

Authors: Carole Beaumont
Journal: Haematologica Date: 2010-08 Impact factor: 9.941

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.

Review 1. Novel redox-sensing modules: accessory protein- and nucleic acid-mediated signaling.

2. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms.

3. Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages.

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Review 10. Air pollutants disrupt iron homeostasis to impact oxidant generation, biological effects, and tissue injury.