Literature DB >> 1848921

Regulated import and degradation of a cytosolic protein in the yeast vacuole.

H L Chiang1, R Schekman.   

Abstract

The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.

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Year:  1991        PMID： 1848921     DOI： 10.1038/350313a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  58 in total

1.  The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway.

Authors:  C Randell Brown; Guo-Chiuan Hung; Danielle Dunton; Hui-Ling Chiang
Journal:  J Biol Chem       Date:  2010-05-10       Impact factor: 5.157

Review 2.  Microautophagy: lesser-known self-eating.

Authors:  Wen-wen Li; Jian Li; Jin-ku Bao
Journal:  Cell Mol Life Sci       Date:  2011-11-12       Impact factor: 9.261

3.  The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system.

Authors:  Sae-Hun Park; Natalia Bolender; Frederik Eisele; Zlatka Kostova; Junko Takeuchi; Philip Coffino; Dieter H Wolf
Journal:  Mol Biol Cell       Date:  2006-10-25       Impact factor: 4.138

Review 4.  The early and late processing of lysosomal enzymes: proteolysis and compartmentation.

Authors:  A Hasilik
Journal:  Experientia       Date:  1992-02-15

5.  The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation.

Authors:  C Randell Brown; Allison B Wolfe; Dongying Cui; Hui-Ling Chiang
Journal:  J Biol Chem       Date:  2008-07-25       Impact factor: 5.157

6.  Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: ubiquitination, endocytosis, and degradation in the vacuole.

Authors:  J Horak; D H Wolf
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

7.  A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation.

Authors:  C Randell Brown; Hui-Ling Chiang
Journal:  Commun Integr Biol       Date:  2009

8.  The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation.

Authors:  C Randell Brown; Danielle Dunton; Hui-Ling Chiang
Journal:  J Biol Chem       Date:  2009-11-05       Impact factor: 5.157

Review 9.  Autophagic proteolysis: control and specificity.

Authors:  E F Blommaart; J J Luiken; A J Meijer
Journal:  Histochem J       Date:  1997-05

10.  Isolation of degradation-deficient mutants defective in the targeting of fructose-1,6-bisphosphatase into the vacuole for degradation in Saccharomyces cerevisiae.

Authors:  M Hoffman; H L Chiang
Journal:  Genetics       Date:  1996-08       Impact factor: 4.562
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